Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 482074..482707 | Replicon | chromosome |
| Accession | NZ_CP053817 | ||
| Organism | Vibrio cholerae strain SA7G | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | HPY17_RS16275 | Protein ID | WP_000843587.1 |
| Coordinates | 482074..482406 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HPY17_RS16280 | Protein ID | WP_000071008.1 |
| Coordinates | 482393..482707 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY17_RS16240 | 477105..478109 | + | 1005 | WP_000964932.1 | LD-carboxypeptidase | - |
| HPY17_RS16245 | 478244..478561 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY17_RS16250 | 478580..478822 | - | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY17_RS16255 | 479284..479394 | + | 111 | WP_076025930.1 | DUF645 family protein | - |
| HPY17_RS16260 | 479545..480279 | + | 735 | WP_114716399.1 | hypothetical protein | - |
| HPY17_RS16265 | 480443..481183 | + | 741 | WP_162813548.1 | PhzF family phenazine biosynthesis protein | - |
| HPY17_RS16270 | 481324..481899 | + | 576 | WP_000199096.1 | class I SAM-dependent methyltransferase | - |
| HPY17_RS16275 | 482074..482406 | + | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY17_RS16280 | 482393..482707 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| HPY17_RS16285 | 482704..482814 | + | 111 | WP_080342631.1 | DUF3265 domain-containing protein | - |
| HPY17_RS16290 | 482822..483139 | - | 318 | WP_000077453.1 | CcdB family protein | - |
| HPY17_RS16295 | 483139..483384 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| HPY17_RS16300 | 483740..483922 | + | 183 | WP_175246448.1 | DUF645 family protein | - |
| HPY17_RS16305 | 484118..484677 | + | 560 | Protein_552 | nucleotidyltransferase domain-containing protein | - |
| HPY17_RS16310 | 484883..485596 | + | 714 | WP_000123660.1 | Fic family protein | - |
| HPY17_RS16315 | 485894..486015 | + | 122 | Protein_554 | DUF645 family protein | - |
| HPY17_RS16320 | 486034..486072 | + | 39 | WP_113612150.1 | hypothetical protein | - |
| HPY17_RS16325 | 486270..486905 | + | 636 | WP_000691786.1 | DUF2807 domain-containing protein | - |
| HPY17_RS16330 | 487068..487637 | + | 570 | WP_053034771.1 | flavodoxin family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 310054..510566 | 200512 | |
| - | inside | Integron | - | - | 311218..510566 | 199348 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T158046 WP_000843587.1 NZ_CP053817:482074-482406 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T158046 NZ_CP069550:7949-8254 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT158046 WP_000071008.1 NZ_CP053817:482393-482707 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT158046 NZ_CP069550:7729-7947 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|