Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 572874..573489 | Replicon | chromosome |
| Accession | NZ_CP053805 | ||
| Organism | Vibrio cholerae strain SL6Y | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | HPY06_RS16180 | Protein ID | WP_001162670.1 |
| Coordinates | 573202..573489 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HPY06_RS16175 | Protein ID | WP_001232701.1 |
| Coordinates | 572874..573191 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY06_RS16130 | 567974..568246 | + | 273 | WP_001915058.1 | DUF1778 domain-containing protein | - |
| HPY06_RS16135 | 568243..568740 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| HPY06_RS16140 | 568901..569224 | - | 324 | WP_017047369.1 | ion tolerance protein CutA | - |
| HPY06_RS16145 | 569382..569666 | - | 285 | WP_043993102.1 | antibiotic biosynthesis monooxygenase | - |
| HPY06_RS16150 | 569837..570223 | - | 387 | WP_175231593.1 | NUDIX hydrolase | - |
| HPY06_RS16155 | 570487..570723 | + | 237 | WP_000772125.1 | RNA-binding protein | - |
| HPY06_RS16160 | 570910..571299 | - | 390 | WP_000491261.1 | VOC family protein | - |
| HPY06_RS16165 | 571657..571866 | - | 210 | WP_113629352.1 | DUF645 family protein | - |
| HPY06_RS16170 | 572130..572726 | - | 597 | WP_175231595.1 | class I SAM-dependent methyltransferase | - |
| HPY06_RS16175 | 572874..573191 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| HPY06_RS16180 | 573202..573489 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY06_RS16185 | 573530..573652 | - | 123 | WP_175231597.1 | acetyltransferase | - |
| HPY06_RS16190 | 573725..574129 | - | 405 | WP_175231599.1 | hypothetical protein | - |
| HPY06_RS16195 | 574415..574693 | + | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY06_RS16200 | 574686..574955 | + | 270 | WP_175231601.1 | type II toxin-antitoxin system YafQ family toxin | - |
| HPY06_RS16205 | 574983..575093 | - | 111 | WP_080478885.1 | DUF3265 domain-containing protein | - |
| HPY06_RS16210 | 575090..576628 | - | 1539 | WP_069648548.1 | RNA-directed DNA polymerase | - |
| HPY06_RS16215 | 576768..577268 | - | 501 | WP_071180357.1 | hypothetical protein | - |
| HPY06_RS16220 | 577425..577748 | - | 324 | WP_017047369.1 | ion tolerance protein CutA | - |
| HPY06_RS16225 | 577924..578265 | - | 342 | WP_055030598.1 | hypothetical protein | - |
| HPY06_RS16230 | 578299..578448 | - | 150 | WP_175231603.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 549333..599478 | 50145 | |
| - | inside | Integron | - | - | 549333..598232 | 48899 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T157953 WP_001162670.1 NZ_CP053805:c573489-573202 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T157953 NZ_CP069522:2489461-2489730 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACACGATT
ACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTACATCCGTTAA
GCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAATGGCGATGCA
TACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACACGATT
ACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTACATCCGTTAA
GCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAATGGCGATGCA
TACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT157953 WP_001232701.1 NZ_CP053805:c573191-572874 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT157953 NZ_CP069522:2489730-2490014 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|