Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 385676..386309 | Replicon | chromosome |
| Accession | NZ_CP053801 | ||
| Organism | Vibrio cholerae strain SO5Y | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | HPY15_RS15320 | Protein ID | WP_000843587.1 |
| Coordinates | 385676..386008 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HPY15_RS15325 | Protein ID | WP_000071008.1 |
| Coordinates | 385995..386309 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY15_RS15290 | 381464..381745 | - | 282 | WP_080341684.1 | DUF1289 domain-containing protein | - |
| HPY15_RS15295 | 381694..381807 | - | 114 | WP_080341690.1 | acetyltransferase | - |
| HPY15_RS15300 | 381863..382243 | - | 381 | WP_046126206.1 | glyoxalase | - |
| HPY15_RS15305 | 382712..383632 | - | 921 | WP_001896359.1 | IS5-like element ISVch8 family transposase | - |
| HPY15_RS15310 | 383936..384940 | + | 1005 | WP_000964932.1 | LD-carboxypeptidase | - |
| HPY15_RS15315 | 385095..385460 | + | 366 | WP_046121679.1 | DUF3465 domain-containing protein | - |
| HPY15_RS15320 | 385676..386008 | + | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY15_RS15325 | 385995..386309 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| HPY15_RS15330 | 386603..386730 | + | 128 | Protein_384 | DUF645 family protein | - |
| HPY15_RS15335 | 386746..386784 | + | 39 | WP_108244118.1 | hypothetical protein | - |
| HPY15_RS15340 | 387287..387424 | + | 138 | WP_000757220.1 | YHYH domain-containing protein | - |
| HPY15_RS15345 | 387616..387978 | + | 363 | WP_162484548.1 | DUF4144 domain-containing protein | - |
| HPY15_RS15350 | 388141..388488 | + | 348 | WP_000933405.1 | hypothetical protein | - |
| HPY15_RS15355 | 388620..389108 | + | 489 | WP_175235995.1 | GNAT family N-acetyltransferase | - |
| HPY15_RS15360 | 389131..390090 | - | 960 | WP_001898459.1 | IS30 family transposase | - |
| HPY15_RS15365 | 390754..391020 | + | 267 | WP_000589156.1 | BrnT family toxin | - |
| HPY15_RS15370 | 391007..391252 | + | 246 | WP_000643598.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 296008..431802 | 135794 | |
| - | inside | Integron | - | - | 370413..382391 | 11978 | |
| - | inside | Integron | - | - | 382712..427017 | 44305 | |
| - | flank | IS/Tn | - | - | 382712..383632 | 920 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T157906 WP_000843587.1 NZ_CP053801:385676-386008 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T157906 NZ_CP069505:c4303-3959 [Acinetobacter pittii]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAATAACACAAGAGAAAGTCTTAGC
TGCGTTGGTTGTTCTGCAACTGCAAGGACCAAGTTTAGGTCGTCCCTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGAGGTAAACCATTAAGAGCATTTTTTGCATTCGATCCATTACGACAAGCAATT
GTACTGTGTATTGGTGATAAGAGCGGTAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATAAGCAATATGAACT
TCATCTCTCAACATTAGGAGAATAA
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAATAACACAAGAGAAAGTCTTAGC
TGCGTTGGTTGTTCTGCAACTGCAAGGACCAAGTTTAGGTCGTCCCTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGAGGTAAACCATTAAGAGCATTTTTTGCATTCGATCCATTACGACAAGCAATT
GTACTGTGTATTGGTGATAAGAGCGGTAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATAAGCAATATGAACT
TCATCTCTCAACATTAGGAGAATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT157906 WP_000071008.1 NZ_CP053801:385995-386309 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT157906 NZ_CP069505:c3954-3652 [Acinetobacter pittii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCTGAGAGCCAAGCCCGTATTCAAAAAATGGCTGATGAATT
GCTATTAGAAAATCAGCTTTACCTTATTCGTGAAGAACTCGAAATCTCTCAAAAAGAACTGGCTGAAACTTTGGGAATAA
AACAGCCATCGCTTTCAGCAATAGAAAATCGTGGCAATGATCTTAAGATTTCAACCATGAAAAAGTATGTTGAAGCTATG
GGAGGAAAGCTCCGTATTGATGTGGAACTTCCAACTGGGAAACATATAGGATTCAATGTATAG
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCTGAGAGCCAAGCCCGTATTCAAAAAATGGCTGATGAATT
GCTATTAGAAAATCAGCTTTACCTTATTCGTGAAGAACTCGAAATCTCTCAAAAAGAACTGGCTGAAACTTTGGGAATAA
AACAGCCATCGCTTTCAGCAATAGAAAATCGTGGCAATGATCTTAAGATTTCAACCATGAAAAAGTATGTTGAAGCTATG
GGAGGAAAGCTCCGTATTGATGTGGAACTTCCAACTGGGAAACATATAGGATTCAATGTATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|