Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 379106..379721 | Replicon | chromosome |
| Accession | NZ_CP053801 | ||
| Organism | Vibrio cholerae strain SO5Y | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | HPY15_RS15275 | Protein ID | WP_001162670.1 |
| Coordinates | 379434..379721 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HPY15_RS15270 | Protein ID | WP_001232701.1 |
| Coordinates | 379106..379423 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY15_RS15215 | 374218..374313 | - | 96 | WP_001907607.1 | DUF645 family protein | - |
| HPY15_RS15220 | 374556..374666 | - | 111 | WP_086017781.1 | DUF3265 domain-containing protein | - |
| HPY15_RS15225 | 375187..375465 | + | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY15_RS15230 | 375458..375727 | + | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | - |
| HPY15_RS15235 | 376323..376748 | - | 426 | WP_052724878.1 | hypothetical protein | - |
| HPY15_RS15240 | 376895..377593 | - | 699 | WP_046126203.1 | HAD family phosphatase | - |
| HPY15_RS15245 | 377684..378241 | - | 558 | WP_046126204.1 | GNAT family N-acetyltransferase | - |
| HPY15_RS15250 | 378238..378336 | - | 99 | WP_142741450.1 | acetyltransferase | - |
| HPY15_RS15255 | 378453..378701 | + | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY15_RS15260 | 378691..378981 | + | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY15_RS15265 | 378999..379109 | - | 111 | WP_082798255.1 | DUF3265 domain-containing protein | - |
| HPY15_RS15270 | 379106..379423 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| HPY15_RS15275 | 379434..379721 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY15_RS15280 | 380073..380281 | - | 209 | Protein_374 | DUF3709 domain-containing protein | - |
| HPY15_RS15285 | 380578..381210 | - | 633 | WP_175235993.1 | hypothetical protein | - |
| HPY15_RS15290 | 381464..381745 | - | 282 | WP_080341684.1 | DUF1289 domain-containing protein | - |
| HPY15_RS15295 | 381694..381807 | - | 114 | WP_080341690.1 | acetyltransferase | - |
| HPY15_RS15300 | 381863..382243 | - | 381 | WP_046126206.1 | glyoxalase | - |
| HPY15_RS15305 | 382712..383632 | - | 921 | WP_001896359.1 | IS5-like element ISVch8 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 296008..431802 | 135794 | |
| - | inside | Integron | - | - | 370413..382391 | 11978 | |
| - | inside | Integron | - | - | 382712..427017 | 44305 | |
| - | flank | IS/Tn | - | - | 382712..383632 | 920 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T157905 WP_001162670.1 NZ_CP053801:c379721-379434 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T157905 NZ_CP069505:1757-2044 [Acinetobacter pittii]
ATGGAACTGTATTTCGAATGGGATGAGGCTAAAAACCAAAAGAATCAGAAAAAACATGATGTATCTTTTGAAACGGCAAG
CCTCGTTTTTGAAGATCCTTTACGGATCTCAATCCAGGATCGACATACCAATGGTGAAGAACGTTGGCAAACGATCGGTA
TGGTTAAAGGTGTACTGATGTTATTGGTGGCTCATACAATCATTGACGATGATGACTGTGAGATCATACGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAACGCAATCAATATGAGCATGGTTAG
ATGGAACTGTATTTCGAATGGGATGAGGCTAAAAACCAAAAGAATCAGAAAAAACATGATGTATCTTTTGAAACGGCAAG
CCTCGTTTTTGAAGATCCTTTACGGATCTCAATCCAGGATCGACATACCAATGGTGAAGAACGTTGGCAAACGATCGGTA
TGGTTAAAGGTGTACTGATGTTATTGGTGGCTCATACAATCATTGACGATGATGACTGTGAGATCATACGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAACGCAATCAATATGAGCATGGTTAG
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT157905 WP_001232701.1 NZ_CP053801:c379423-379106 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT157905 NZ_CP069505:2031-2342 [Acinetobacter pittii]
ATGAGCATGGTTAGATATACACGCAAAGAACTGAATGAAAAATTCAGTGACAAGCAAGATGCTGAAATTAAACGCTTGCT
TGCAAAAGGAACTGTACCAGATGAACAATTAGATCTATCTGACATTCCTGAGATTACCGACTGGAGTCATGCTGTTCGCC
ATGGGCAATTTTATCGTCCAGTGAAGCAACAAACATCTGTTCGTCTAGATGCAGATGTACTTGCATGGTTAAAGGCTCAA
GGCAAAGGCTATCAGACACGCATGAATAAAATTCTGCGTGAAGCAATGCTAGAAGATCTTAAGAATCATTGA
ATGAGCATGGTTAGATATACACGCAAAGAACTGAATGAAAAATTCAGTGACAAGCAAGATGCTGAAATTAAACGCTTGCT
TGCAAAAGGAACTGTACCAGATGAACAATTAGATCTATCTGACATTCCTGAGATTACCGACTGGAGTCATGCTGTTCGCC
ATGGGCAATTTTATCGTCCAGTGAAGCAACAAACATCTGTTCGTCTAGATGCAGATGTACTTGCATGGTTAAAGGCTCAA
GGCAAAGGCTATCAGACACGCATGAATAAAATTCTGCGTGAAGCAATGCTAGAAGATCTTAAGAATCATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|