Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 357052..357667 | Replicon | chromosome |
Accession | NZ_CP053795 | ||
Organism | Vibrio cholerae strain W10G |
Toxin (Protein)
Gene name | higB | Uniprot ID | Q9KMG5 |
Locus tag | HPY12_RS15550 | Protein ID | WP_001162670.1 |
Coordinates | 357052..357339 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | HPY12_RS15555 | Protein ID | WP_001898235.1 |
Coordinates | 357350..357667 (+) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HPY12_RS15510 | 352590..352772 | + | 183 | WP_019281482.1 | DUF645 family protein | - |
HPY12_RS15515 | 352887..352970 | + | 84 | WP_080099571.1 | acetyltransferase | - |
HPY12_RS15520 | 352983..353342 | + | 360 | WP_175234259.1 | VOC family protein | - |
HPY12_RS15525 | 353639..353818 | + | 180 | WP_080389342.1 | DUF645 family protein | - |
HPY12_RS15530 | 354019..354507 | + | 489 | WP_057569088.1 | hypothetical protein | - |
HPY12_RS15535 | 355097..355612 | + | 516 | Protein_326 | ClbS/DfsB family four-helix bundle protein | - |
HPY12_RS15540 | 355920..356102 | + | 183 | WP_043992545.1 | DUF645 family protein | - |
HPY12_RS15545 | 356391..356816 | + | 426 | WP_001898239.1 | hypothetical protein | - |
HPY12_RS15550 | 357052..357339 | + | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HPY12_RS15555 | 357350..357667 | + | 318 | WP_001898235.1 | HigA family addiction module antidote protein | Antitoxin |
HPY12_RS15560 | 357787..358302 | + | 516 | WP_000090010.1 | hypothetical protein | - |
HPY12_RS15565 | 358564..358800 | + | 237 | Protein_332 | DUF3709 domain-containing protein | - |
HPY12_RS15570 | 359088..359417 | + | 330 | WP_043990318.1 | DHCW motif cupin fold protein | - |
HPY12_RS15575 | 359728..359853 | + | 126 | WP_080285473.1 | DUF645 family protein | - |
HPY12_RS15580 | 359869..359907 | + | 39 | WP_148506239.1 | hypothetical protein | - |
HPY12_RS15585 | 360092..360382 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
HPY12_RS15590 | 360372..360620 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
HPY12_RS15595 | 360862..361185 | + | 324 | WP_080375416.1 | DUF3709 domain-containing protein | - |
HPY12_RS15600 | 361459..362463 | + | 1005 | WP_000964934.1 | LD-carboxypeptidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 306166..386842 | 80676 | |
- | inside | Integron | - | - | 307330..385669 | 78339 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T157861 WP_001162670.1 NZ_CP053795:357052-357339 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T157861 NZ_CP069499:c115424-115275 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11689.63 Da Isoelectric Point: 10.6504
>AT157861 WP_001898235.1 NZ_CP053795:357350-357667 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRFQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRFQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT157861 NZ_CP069499:115472-115528 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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