Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 269496..270009 Replicon chromosome
Accession NZ_CP053792
Organism Streptococcus canis strain HL_77_1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GE021_RS01420 Protein ID WP_141290611.1
Coordinates 269755..270009 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GE021_RS01415 Protein ID WP_141290609.1
Coordinates 269496..269762 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE021_RS01375 265498..266739 + 1242 WP_141290593.1 replication initiation factor domain-containing protein -
GE021_RS01380 266720..267079 + 360 WP_141290595.1 hypothetical protein -
GE021_RS01385 267076..267429 + 354 WP_141290597.1 hypothetical protein -
GE021_RS01390 267484..267723 + 240 WP_141290599.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GE021_RS01395 267720..268007 + 288 WP_141290601.1 Txe/YoeB family addiction module toxin -
GE021_RS01400 268223..268498 + 276 WP_141290603.1 hypothetical protein -
GE021_RS01405 268554..268922 + 369 WP_141290605.1 hypothetical protein -
GE021_RS01410 268931..269407 + 477 WP_141290607.1 DUF2309 domain-containing protein -
GE021_RS01415 269496..269762 + 267 WP_141290609.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GE021_RS01420 269755..270009 + 255 WP_141290611.1 Txe/YoeB family addiction module toxin Toxin
GE021_RS01425 270055..271005 + 951 WP_141290613.1 conjugal transfer protein -
GE021_RS01430 271024..271293 + 270 WP_011285000.1 hypothetical protein -
GE021_RS01435 271296..271706 + 411 WP_141290615.1 conjugal transfer protein -
GE021_RS01440 271727..274228 + 2502 WP_164227714.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 216962..270565 53603


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10415.76 Da        Isoelectric Point: 7.3975

>T157853 WP_141290611.1 NZ_CP053792:269755-270009 [Streptococcus canis]
MFNFTDEAWRDYVSWQHEDKKVLKRINRLIEDIKRNPFEGIGKPESLKYHYSGAWSRRITEEHRLVYMVEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T157853 NZ_CP069496:3303437-3303826 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCGTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATTTTGCTTTATCAGTTATTAACGCCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCTCAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACCGTGGGGAAATTACTAAAATAATTGATTATCAGTTATTTGTGGTTATTTATCTTGAAGAAACTCCTACGAACATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10267.65 Da        Isoelectric Point: 4.8177

>AT157853 WP_141290609.1 NZ_CP053792:269496-269762 [Streptococcus canis]
MEAVVYSNFRNNLKDYMKKVNDEFEPLIVVNKNPNENIVVLSQNSWESLQETIRVMENDYLSHKVINGMSQVKEKQVTKH
DLIGVEDV

Download         Length: 267 bp

>AT157853 NZ_CP069496:3303173-3303430 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAATTATTATTTAAAAGCTGATCCGGCTGAAAAAGCATTATTTGCAGAGTTGGTTGATCAAGAAG
ATCCAGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References