Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3921536..3922229 Replicon chromosome
Accession NZ_CP053787
Organism Escherichia coli isolate J31

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HQN81_RS18950 Protein ID WP_000415584.1
Coordinates 3921933..3922229 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HQN81_RS18945 Protein ID WP_000650107.1
Coordinates 3921536..3921931 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQN81_RS18935 3917400..3919658 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
HQN81_RS18940 3919796..3921403 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HQN81_RS18945 3921536..3921931 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HQN81_RS18950 3921933..3922229 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HQN81_RS18955 3922434..3922916 - 483 WP_000183505.1 transcriptional regulator -
HQN81_RS18960 3922969..3923361 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HQN81_RS18965 3923513..3924172 + 660 WP_001221493.1 two-component system response regulator QseB -
HQN81_RS18970 3924169..3925518 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
HQN81_RS18975 3925564..3925896 - 333 WP_000917684.1 DUF2645 family protein -
HQN81_RS18980 3926215..3926796 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HQN81_RS18985 3926827..3927141 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T157838 WP_000415584.1 NZ_CP053787:c3922229-3921933 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T157838 NZ_CP069488:c3672456-3672172 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT157838 WP_000650107.1 NZ_CP053787:c3921931-3921536 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT157838 NZ_CP069488:c3672692-3672459 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References