Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1833836..1834338 Replicon chromosome
Accession NZ_CP053785
Organism Escherichia coli isolate 2-101

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HQN80_RS08690 Protein ID WP_001471733.1
Coordinates 1834084..1834338 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HQN80_RS08685 Protein ID WP_001259255.1
Coordinates 1833836..1834087 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQN80_RS08660 1829014..1830081 - 1068 WP_001374028.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HQN80_RS08665 1830081..1831151 - 1071 WP_001374029.1 histidinol-phosphate transaminase -
HQN80_RS08670 1831148..1832452 - 1305 WP_001748534.1 histidinol dehydrogenase -
HQN80_RS08675 1832458..1833357 - 900 WP_000131793.1 ATP phosphoribosyltransferase -
HQN80_RS08680 1833503..1833553 - 51 WP_001364200.1 his operon leader peptide -
HQN80_RS08685 1833836..1834087 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HQN80_RS08690 1834084..1834338 + 255 WP_001471733.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HQN80_RS08695 1834421..1835245 + 825 WP_000754737.1 SDR family oxidoreductase -
HQN80_RS08700 1835291..1836220 + 930 WP_000803351.1 LysR family transcriptional regulator -
HQN80_RS08705 1836435..1836497 + 63 WP_010723108.1 membrane protein YoeI -
HQN80_RS08710 1836487..1837845 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HQN80_RS08715 1838024..1839082 + 1059 WP_000492324.1 transport protein YeeE -
HQN80_RS08720 1839096..1839323 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T157801 WP_001471733.1 NZ_CP053785:1834084-1834338 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDIRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T157801 NZ_CP069480:1570079-1570231 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT157801 WP_001259255.1 NZ_CP053785:1833836-1834087 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT157801 NZ_CP069480:c1570030-1569973 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References