Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 53792..54056 Replicon plasmid pMHMC-003
Accession NZ_CP053754
Organism Shigella sonnei strain 506

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag COO90_RS26460 Protein ID WP_001331364.1
Coordinates 53792..53944 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 53999..54056 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COO90_RS26430 (49069) 49069..51237 + 2169 WP_000698357.1 DotA/TraY family protein -
COO90_RS26435 (51311) 51311..51961 + 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
COO90_RS26440 (52033) 52033..52242 - 210 WP_000062603.1 HEAT repeat domain-containing protein -
COO90_RS26445 (52634) 52634..52810 + 177 WP_001054898.1 hypothetical protein -
COO90_RS27490 (52875) 52875..52970 - 96 WP_001303310.1 DinQ-like type I toxin DqlB -
COO90_RS26455 (53469) 53469..53720 + 252 WP_001291964.1 hypothetical protein -
COO90_RS26460 (53792) 53792..53944 - 153 WP_001331364.1 Hok/Gef family protein Toxin
- (53999) 53999..54056 + 58 NuclAT_0 - Antitoxin
- (53999) 53999..54056 + 58 NuclAT_0 - Antitoxin
- (53999) 53999..54056 + 58 NuclAT_0 - Antitoxin
- (53999) 53999..54056 + 58 NuclAT_0 - Antitoxin
- (54297) 54297..54352 + 56 NuclAT_1 - -
- (54297) 54297..54352 + 56 NuclAT_1 - -
- (54297) 54297..54352 + 56 NuclAT_1 - -
- (54297) 54297..54352 + 56 NuclAT_1 - -
COO90_RS26465 (54546) 54546..55499 + 954 WP_021513958.1 hypothetical protein -
COO90_RS26470 (55717) 55717..56925 + 1209 WP_001383960.1 IncI1-type conjugal transfer protein TrbA -
COO90_RS26475 (56944) 56944..58014 + 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..88060 88060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T157731 WP_001331364.1 NZ_CP053754:c53944-53792 [Shigella sonnei]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T157731 NZ_CP069451:c4957030-4956923 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 58 bp

>AT157731 NZ_CP053754:53999-54056 [Shigella sonnei]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References