Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 403014..403629 Replicon chromosome
Accession NZ_CP053745
Organism Vibrio cholerae strain SA3G

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag HPY04_RS15625 Protein ID WP_001162670.1
Coordinates 403014..403301 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HPY04_RS15630 Protein ID WP_001232701.1
Coordinates 403312..403629 (+) Length 106 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY04_RS15590 398571..398897 + 327 WP_175249420.1 hypothetical protein -
HPY04_RS15595 399112..399357 - 246 WP_175249421.1 hypothetical protein -
HPY04_RS15600 399916..400263 + 348 WP_001071511.1 VOC family protein -
HPY04_RS15605 400383..401045 + 663 WP_000084911.1 Vat family streptogramin A O-acetyltransferase -
HPY04_RS15610 401341..401523 + 183 WP_000923154.1 DUF645 family protein -
HPY04_RS15615 402222..402782 + 561 WP_175249422.1 nucleotidyltransferase domain-containing protein -
HPY04_RS15620 402851..402973 + 123 WP_175249423.1 acetyltransferase -
HPY04_RS15625 403014..403301 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY04_RS15630 403312..403629 + 318 WP_001232701.1 HigA family addiction module antidote protein Antitoxin
HPY04_RS15635 403773..404312 + 540 WP_175231429.1 hydrolase -
HPY04_RS15640 404463..404888 + 426 WP_095462070.1 GNAT family N-acetyltransferase -
HPY04_RS15645 405238..405333 + 96 WP_175249424.1 DUF645 family protein -
HPY04_RS15650 405543..406001 + 459 WP_032473158.1 GNAT family N-acetyltransferase -
HPY04_RS15655 406318..406497 + 180 WP_050547145.1 DUF645 family protein -
HPY04_RS15660 406646..406807 + 162 Protein_398 DUF3709 domain-containing protein -
HPY04_RS15665 406843..406995 + 153 WP_175242275.1 DUF3709 domain-containing protein -
HPY04_RS15670 407459..407668 + 210 WP_175249665.1 DUF645 family protein -
HPY04_RS15675 407879..408262 + 384 WP_175249425.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 336942..428561 91619
- inside Integron - - 388738..428561 39823


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-95)

Antitoxin

(12-69)


Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T157687 WP_001162670.1 NZ_CP053745:403014-403301 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T157687 NZ_CP069447:c412300-411875 [Escherichia coli]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCTCCTGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCAATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGGTCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTGCGGGCGCGGCAGGCGACCGGCCTGCGGATTCAGTG
CAAAAACACGAATATAATCAGCCGGATGGCTGATTCAAGACATGATAAAAGACTTTACCAGCGCACGTTTAAAGCGTGCA
AGAGATGTTATTATACTAAAACATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT157687 WP_001232701.1 NZ_CP053745:403312-403629 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT157687 NZ_CP069447:c412666-412331 [Escherichia coli]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGTTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCCCCTGCCAACAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0F2HI36


Antitoxin

Source ID Structure

References