157659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1898304..1899880 Replicon chromosome
Accession NZ_CP053736
Organism Escherichia coli strain CP8-3_Sichuan

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HP430_RS09090 Protein ID WP_172614266.1
Coordinates 1898304..1899614 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HP430_RS09095 Protein ID WP_001301023.1
Coordinates 1899614..1899880 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP430_RS09065 1894270..1895184 - 915 WP_000520676.1 fimbrial protein -
HP430_RS09070 1895243..1895746 - 504 WP_000825452.1 type 1 fimbrial protein -
HP430_RS09075 1895759..1896289 - 531 WP_000876763.1 type 1 fimbrial protein -
HP430_RS09080 1896303..1897529 - 1227 Protein_1773 fimbrial biogenesis outer membrane usher protein -
HP430_RS09085 1897784..1897992 - 209 Protein_1774 helix-turn-helix transcriptional regulator -
HP430_RS09090 1898304..1899614 - 1311 WP_172614266.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
HP430_RS09095 1899614..1899880 - 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HP430_RS09100 1900103..1904532 - 4430 Protein_1777 autotransporter barrel domain-containing lipoprotein -
HP430_RS09105 1904599..1904670 - 72 Protein_1778 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1888292..1904670 16378


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-397)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48892.37 Da        Isoelectric Point: 8.2482

>T157659 WP_172614266.1 NZ_CP053736:c1899614-1898304 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELPDAEIIKAGNVRALAVERFDRRWNAER
TVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGS
YRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALD
NVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1311 bp

>T157659 NZ_CP069441:c5008339-5008061 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT157659 WP_001301023.1 NZ_CP053736:c1899880-1899614 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT157659 NZ_CP069441:c5008061-5007777 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References