157614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4569475..4570168 Replicon chromosome
Accession NZ_CP053730
Organism Escherichia coli strain CP61_Sichuan

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HP432_RS22880 Protein ID WP_000415584.1
Coordinates 4569872..4570168 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HP432_RS22875 Protein ID WP_000650107.1
Coordinates 4569475..4569870 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP432_RS22865 4565339..4567597 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
HP432_RS22870 4567735..4569342 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HP432_RS22875 4569475..4569870 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HP432_RS22880 4569872..4570168 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HP432_RS22885 4570373..4570855 - 483 WP_000183505.1 transcriptional regulator -
HP432_RS22890 4570908..4571300 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HP432_RS22895 4571452..4572111 + 660 WP_001221493.1 two-component system response regulator QseB -
HP432_RS22900 4572108..4573457 + 1350 WP_172615832.1 two-component system sensor histidine kinase QseC -
HP432_RS22905 4573503..4573835 - 333 WP_000917684.1 DUF2645 family protein -
HP432_RS22910 4574154..4574735 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HP432_RS22915 4574766..4575080 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T157614 WP_000415584.1 NZ_CP053730:c4570168-4569872 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T157614 NZ_CP069430:490539-490889 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT157614 WP_000650107.1 NZ_CP053730:c4569870-4569475 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT157614 NZ_CP069430:490252-490533 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References