Detailed information of TA system TA157596

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2825232..2825603
• Replicon: chromosome
• Accession: NZ_CP053730
• Organism: Escherichia coli strain CP61_Sichuan

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A7W3G0W6
• Locus tag: HP432_RS14500
• Protein ID: WP_072130784.1
• Coordinates: 2825409..2825603 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2825232..2825410 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP432_RS14475	2821187..2822560	+	1374	WP_000123720.1	ATP-dependent RNA helicase DbpA	-
HP432_RS14480	2822689..2823624	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
HP432_RS14485	2823676..2824911	-	1236	WP_072195204.1	site-specific integrase	-
HP432_RS14490	2824913..2825128	-	216	WP_000079604.1	excisionase XisR	-
HP432_RS14495	2825228..2825416	-	189	WP_001302840.1	DUF1187 family protein	-
-	2825232..2825410	+	179	NuclAT_0	-	Antitoxin
-	2825232..2825410	+	179	NuclAT_0	-	Antitoxin
-	2825232..2825410	+	179	NuclAT_0	-	Antitoxin
-	2825232..2825410	+	179	NuclAT_0	-	Antitoxin
HP432_RS14500	2825409..2825603	-	195	WP_072130784.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
HP432_RS14505	2825660..2826493	-	834	WP_000166322.1	recombination protein RecT	-
HP432_RS14510	2826486..2828681	-	2196	WP_172615842.1	exodeoxyribonuclease VIII	-
HP432_RS14515	2828660..2828845	+	186	Protein_2637	hypothetical protein	-
HP432_RS14520	2828852..2829598	+	747	WP_000788982.1	ATP-binding protein	-
HP432_RS14525	2829621..2830346	+	726	WP_172615843.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2823676..2845985	22309

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7135.00 Da
• Isoelectric Point: 8.0115

>T157596 WP_072130784.1 NZ_CP053730:c2825603-2825409 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV

Nucleotide

• Length: 195 bp

>T157596 NZ_CP069386:c2326897-2326790 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT157596 NZ_CP053730:2825232-2825410 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7W3G0W6

Antitoxin