Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5489355..5489950 Replicon chromosome
Accession NZ_CP053705
Organism Pseudomonas aeruginosa strain PAC6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HPT10_RS25445 Protein ID WP_071548386.1
Coordinates 5489672..5489950 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HPT10_RS25440 Protein ID WP_003133769.1
Coordinates 5489355..5489660 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPT10_RS25405 5484496..5485344 + 849 WP_171889304.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
HPT10_RS25415 5485511..5486452 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
HPT10_RS25420 5486569..5487183 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
HPT10_RS25425 5487225..5487809 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
HPT10_RS25430 5487850..5488950 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
HPT10_RS25440 5489355..5489660 - 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
HPT10_RS25445 5489672..5489950 - 279 WP_071548386.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPT10_RS25450 5490279..5492507 + 2229 WP_073647417.1 TonB-dependent receptor -
HPT10_RS25455 5492578..5493225 - 648 WP_003095021.1 carbonate dehydratase -
HPT10_RS25460 5493287..5494525 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10670.18 Da        Isoelectric Point: 7.9184

>T157490 WP_071548386.1 NZ_CP053705:c5489950-5489672 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAIHTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T157490 NZ_CP069329:c143237-142956 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT157490 WP_003133769.1 NZ_CP053705:c5489660-5489355 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT157490 NZ_CP069329:c143461-143234 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References