Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1226879..1227513 Replicon chromosome
Accession NZ_CP053685
Organism Proteus mirabilis strain MPE5203

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HOY68_RS05385 Protein ID WP_175215574.1
Coordinates 1227220..1227513 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HOY68_RS05380 Protein ID WP_175215573.1
Coordinates 1226879..1227205 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HOY68_RS05370 1222819..1225971 - 3153 WP_175215571.1 DEAD/DEAH box helicase -
HOY68_RS05375 1225961..1226809 - 849 WP_175215572.1 DUF1837 domain-containing protein -
HOY68_RS05380 1226879..1227205 - 327 WP_175215573.1 HigA family addiction module antidote protein Antitoxin
HOY68_RS05385 1227220..1227513 - 294 WP_175215574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HOY68_RS05390 1227643..1228854 - 1212 WP_175215575.1 site-specific integrase -
HOY68_RS05395 1229026..1229889 - 864 WP_004249947.1 YicC family protein -
HOY68_RS05400 1230016..1230732 + 717 WP_004249760.1 ribonuclease PH -
HOY68_RS05405 1230814..1231458 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
HOY68_RS05410 1231778..1232383 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11429.88 Da        Isoelectric Point: 5.1406

>T157461 WP_175215574.1 NZ_CP053685:c1227513-1227220 [Proteus mirabilis]
MAVEFRDTWLEAFYEDDQSHRKIPSTIEGALFRKLEILDAATQESDLRIPPGNRFEHLEGNMAGWCSIRVNKQYRLIFRW
IDGIAQDTYLDPHVYRG

Download         Length: 294 bp

>T157461 NZ_CP069324:1568799-1569668 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACACCCCCGTCCCGAACCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGCCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCTTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGTCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12351.41 Da        Isoelectric Point: 10.0847

>AT157461 WP_175215573.1 NZ_CP053685:c1227205-1226879 [Proteus mirabilis]
MRNTKRRPVTVGQMLVTEFLEPMNIEINELAEAMGVHRNTLSRIVHDKGALTAPMAIKLAAALGNTPEFWLNIQHSVELW
DVRHRAFEQEAKNVKRVTPLLEKREALI

Download         Length: 327 bp

>AT157461 NZ_CP069324:1569661-1570494 [Pseudomonas aeruginosa]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTTTCGCCGTCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGAACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References