Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HTH_37(antitoxin) |
| Location | 2142223..2142861 | Replicon | chromosome |
| Accession | NZ_CP053676 | ||
| Organism | MAG: Ferrovum myxofaciens isolate S2.4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | HO274_RS10525 | Protein ID | WP_273119435.1 |
| Coordinates | 2142223..2142456 (+) | Length | 78 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HO274_RS10530 | Protein ID | WP_273119438.1 |
| Coordinates | 2142541..2142861 (+) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HO274_RS10485 (HO274_10440) | 2138029..2138421 | - | 393 | WP_273119410.1 | type II toxin-antitoxin system VapC family toxin | - |
| HO274_RS10490 (HO274_10445) | 2138436..2138666 | - | 231 | WP_273119413.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| HO274_RS10495 (HO274_10450) | 2138663..2139259 | - | 597 | WP_273119415.1 | EAL domain-containing protein | - |
| HO274_RS10500 (HO274_10455) | 2139276..2140004 | - | 729 | WP_273119417.1 | PEP-CTERM sorting domain-containing protein | - |
| HO274_RS10505 (HO274_10460) | 2140188..2140589 | - | 402 | WP_273119419.1 | type II toxin-antitoxin system VapC family toxin | - |
| HO274_RS10510 | 2140589..2140978 | - | 390 | WP_273119423.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| HO274_RS10515 (HO274_10470) | 2141024..2141437 | - | 414 | WP_273119428.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| HO274_RS10520 (HO274_10475) | 2141572..2142051 | + | 480 | WP_273119431.1 | hypothetical protein | - |
| HO274_RS10525 (HO274_10480) | 2142223..2142456 | + | 234 | WP_273119435.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HO274_RS10530 (HO274_10485) | 2142541..2142861 | + | 321 | WP_273119438.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HO274_RS10535 (HO274_10490) | 2143998..2144264 | + | 267 | Protein_2060 | BrnT family toxin | - |
| HO274_RS10540 (HO274_10495) | 2144242..2144562 | + | 321 | WP_273119441.1 | BrnA antitoxin family protein | - |
| HO274_RS10545 (HO274_10500) | 2144713..2144985 | + | 273 | WP_273119444.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HO274_RS10550 (HO274_10505) | 2144976..2145398 | + | 423 | WP_031598929.1 | type II toxin-antitoxin system VapC family toxin | - |
| HO274_RS10555 (HO274_10515) | 2145916..2146263 | + | 348 | WP_273119449.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HO274_RS10560 (HO274_10520) | 2146256..2146861 | + | 606 | WP_273119452.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2106482..2343663 | 237181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 78 a.a. Molecular weight: 8515.70 Da Isoelectric Point: 6.7212
>T157428 WP_273119435.1 NZ_CP053676:2142223-2142456 [Ferrovum myxofaciens]
MAYSVEYFHAKVQASVETWPVDVVADYARIIELLVEHGPSLRLPHSRAFGGGLFELRPRGNSGIERASIVFLSGSAW
MAYSVEYFHAKVQASVETWPVDVVADYARIIELLVEHGPSLRLPHSRAFGGGLFELRPRGNSGIERASIVFLSGSAW
Download Length: 234 bp
>T157428 NZ_CP069308:915435-915779 [Glaesserella parasuis]
ATGGAAACAGAAGAATATCTTACTTTTATTAAAACCAAAGTTTTTGAAGAAGACCGAAAAGCATTAATGTCTGATGATGA
ATATCAGAAATTTCAGGCTTATTTATTAGAATCTCACGAATTAGGCGATTTTATTCAGAATACTGGTGGTTGCCAAAAAA
TTCGCTGGAAACTAGAAAGTAATAACAAGGGCAAAAGTGGTGGTGTAAGGGTGATTTACTATGTTGTAACCAAACAGGGA
AAATTATTATTAATGATGATGTATGCTAAAAGCAAACAAGACAATATGAGTGATAAACAAAAAGCAATGTTAAAAGCGGT
TGTATCCCAATTAAGTGAGGAGTAA
ATGGAAACAGAAGAATATCTTACTTTTATTAAAACCAAAGTTTTTGAAGAAGACCGAAAAGCATTAATGTCTGATGATGA
ATATCAGAAATTTCAGGCTTATTTATTAGAATCTCACGAATTAGGCGATTTTATTCAGAATACTGGTGGTTGCCAAAAAA
TTCGCTGGAAACTAGAAAGTAATAACAAGGGCAAAAGTGGTGGTGTAAGGGTGATTTACTATGTTGTAACCAAACAGGGA
AAATTATTATTAATGATGATGTATGCTAAAAGCAAACAAGACAATATGAGTGATAAACAAAAAGCAATGTTAAAAGCGGT
TGTATCCCAATTAAGTGAGGAGTAA
Antitoxin
Download Length: 107 a.a. Molecular weight: 11758.57 Da Isoelectric Point: 9.4837
>AT157428 WP_273119438.1 NZ_CP053676:2142541-2142861 [Ferrovum myxofaciens]
MADLKYDPVPHNQKDFLEKASKRRGFCEVYDALETEYALVHEMLSARTRAGLTQEAVADRMGTTKSAVSRLEGAGRHAPS
MASLKKYAAAVGCTLKIEFIPQPMKR
MADLKYDPVPHNQKDFLEKASKRRGFCEVYDALETEYALVHEMLSARTRAGLTQEAVADRMGTTKSAVSRLEGAGRHAPS
MASLKKYAAAVGCTLKIEFIPQPMKR
Download Length: 321 bp
>AT157428 NZ_CP069308:915782-916042 [Glaesserella parasuis]
ATGGAAAAAGAACTTTTTGAACGTCTAATGGAAAGTGCGAGAGAAATGGTCGCCATTGAAAAAGGCGAAATAGAAGTACC
ACCGCATCGTATTCATATCCATAAAATCCCGAATGTCAAAGCGATTAGAACCCAGCACCAGATGAAACAAGCGGAATTTG
CTTCCCTTTTAGGCGTAAGCCAAAATCTTGTGCAGTCGTGGGAAATCGGCAGACGAACCCCAAATGGCGCTGCACGGGAC
CCTATCCCAAATTCTGTGTAA
ATGGAAAAAGAACTTTTTGAACGTCTAATGGAAAGTGCGAGAGAAATGGTCGCCATTGAAAAAGGCGAAATAGAAGTACC
ACCGCATCGTATTCATATCCATAAAATCCCGAATGTCAAAGCGATTAGAACCCAGCACCAGATGAAACAAGCGGAATTTG
CTTCCCTTTTAGGCGTAAGCCAAAATCTTGTGCAGTCGTGGGAAATCGGCAGACGAACCCCAAATGGCGCTGCACGGGAC
CCTATCCCAAATTCTGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|