Detailed information of TA system TA157414

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1075243..1075892
• Replicon: chromosome
• Accession: NZ_CP053675
• Organism: MAG: Ferrovum myxofaciens isolate MI1A

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A8F3DXY1
• Locus tag: HO273_RS05245
• Protein ID: WP_031599590.1
• Coordinates: 1075243..1075581 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8F3E163
• Locus tag: HO273_RS05250
• Protein ID: WP_031599591.1
• Coordinates: 1075578..1075892 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HO273_RS05210 (HO273_04745)	1070259..1070843	+	585	WP_273145884.1	chorismate lyase	-
HO273_RS05215 (HO273_04750)	1070922..1071563	+	642	WP_062187741.1	response regulator transcription factor	-
HO273_RS05220 (HO273_04755)	1071571..1073706	-	2136	WP_273145885.1	DUF748 domain-containing protein	-
HO273_RS05225 (HO273_04760)	1073710..1073862	-	153	WP_273145886.1	hypothetical protein	-
HO273_RS05230 (HO273_04765)	1073859..1074293	-	435	WP_150112405.1	cytochrome C	-
HO273_RS05235 (HO273_04770)	1074464..1074790	-	327	WP_031596839.1	type II toxin-antitoxin system PemK/MazF family toxin	-
HO273_RS05240 (HO273_04775)	1074787..1075008	-	222	WP_082783138.1	antitoxin MazE family protein	-
HO273_RS05245 (HO273_04780)	1075243..1075581	+	339	WP_031599590.1	toxin	Toxin
HO273_RS05250 (HO273_04785)	1075578..1075892	+	315	WP_031599591.1	transcriptional regulator	Antitoxin
HO273_RS05255 (HO273_04795)	1076398..1076619	-	222	WP_082783138.1	antitoxin MazE family protein	-
HO273_RS05260 (HO273_04800)	1076788..1077210	-	423	WP_031599221.1	type II toxin-antitoxin system VapC family toxin	-
HO273_RS05265 (HO273_04805)	1077207..1077521	-	315	WP_031599223.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
HO273_RS05270 (HO273_04810)	1077848..1079743	-	1896	WP_062187752.1	GGDEF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (42-101)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13116.21 Da
• Isoelectric Point: 10.4094

>T157414 WP_031599590.1 NZ_CP053675:1075243-1075581 [Ferrovum myxofaciens]
MKALFVELPSFARFRADYLSDDSFRALQNTLMKNPEAGDIIEGSGGLRKLRHADVKRGKGKRGGLRVIYFWWNAGRQFWL
FTLYDKNEMDDLTMKGKGLLRDMLKLELEERR

Nucleotide

• Length: 339 bp

>T157414 NZ_CP069278:c67576-67241 [Bifidobacterium longum]
ATGCTCAAACCGGATTACACGGCGGCATTCCAGCGAGATATCAAGAAGCTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTACTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTTGGGCAAATAGCGGGTTTACATCCTGCTTTGAACCA
GCCGACGGCGATTTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12006.75 Da
• Isoelectric Point: 9.8220

>AT157414 WP_031599591.1 NZ_CP053675:1075578-1075892 [Ferrovum myxofaciens]
MKNRNLFAEIAEGFNALAEERAGKRTLRTHEVDMIPTSEVTADELLALREKLNLSRPVFARYLRTNPRTLENWEQGRARP
NAQAALLIRLVERYPDTMERLATV

Nucleotide

• Length: 315 bp

>AT157414 NZ_CP069278:c67849-67580 [Bifidobacterium longum]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAAGCGCATTCCCCTAAACCTTTCCTATACGA
TCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCAACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA