Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4366596..4366854 Replicon chromosome
Accession NZ_CP053662
Organism Escherichia coli strain eco-241

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag HPK14_RS21385 Protein ID WP_000809168.1
Coordinates 4366702..4366854 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4366596..4366653 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPK14_RS21370 4362988..4363947 + 960 WP_000871674.1 hypothetical protein -
HPK14_RS21375 4363985..4364884 - 900 WP_001300855.1 transcriptional activator NhaR -
HPK14_RS21380 4364950..4366116 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4366596..4366653 - 58 - - Antitoxin
HPK14_RS21385 4366702..4366854 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
HPK14_RS21390 4366958..4368088 - 1131 WP_001118464.1 molecular chaperone DnaJ -
HPK14_RS21395 4368177..4370093 - 1917 WP_000516135.1 molecular chaperone DnaK -
HPK14_RS21400 4370469..4370873 + 405 WP_000843584.1 DUF2541 family protein -
HPK14_RS21405 4370899..4371612 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T157371 WP_000809168.1 NZ_CP053662:4366702-4366854 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T157371 NZ_CP069194:54841-55092 [Vibrio diabolicus]
ATGGATGCCATCAGTTATACCGCGGCGAGAGCGAATCTGGCAAGTACCATGGAAAAAGTCTGTAATGATCACGCGCCGGT
TATTATTACACGTAAAAGTGAAGCGCCTGTGGTGATGATGTCACTTGAAGATTATGAAGCGATGCAAGAAACCACGTATC
TTTTACGTGCACCAGCCAATGCCCGTCGATTGCTCGAGTCGATAGTCGAACTCGAGTCAGGAAAAGGGCAAGAGAGAGAA
CTGCTCGAATGA

Antitoxin


Download         Length: 58 bp

>AT157371 NZ_CP053662:c4366653-4366596 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References