Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 741148..741841 Replicon chromosome
Accession NZ_CP053662
Organism Escherichia coli strain eco-241

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HPK14_RS03615 Protein ID WP_000415584.1
Coordinates 741148..741444 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HPK14_RS03620 Protein ID WP_000650107.1
Coordinates 741446..741841 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPK14_RS03580 (736236) 736236..736550 - 315 WP_000958598.1 putative quinol monooxygenase -
HPK14_RS03585 (736581) 736581..737162 - 582 WP_000072421.1 NADPH:quinone oxidoreductase MdaB -
HPK14_RS03590 (737481) 737481..737813 + 333 WP_000917684.1 DUF2645 family protein -
HPK14_RS03595 (737859) 737859..739208 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HPK14_RS03600 (739205) 739205..739864 - 660 WP_001221510.1 quorum sensing response regulator transcription factor QseB -
HPK14_RS03605 (740016) 740016..740408 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HPK14_RS03610 (740461) 740461..740943 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HPK14_RS03615 (741148) 741148..741444 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HPK14_RS03620 (741446) 741446..741841 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HPK14_RS03625 (741974) 741974..743581 + 1608 WP_001735743.1 ABC transporter substrate-binding protein -
HPK14_RS03630 (743719) 743719..745977 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T157353 WP_000415584.1 NZ_CP053662:741148-741444 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T157353 NZ_CP069173:6163-6444 [Klebsiella pneumoniae]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT157353 WP_000650107.1 NZ_CP053662:741446-741841 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT157353 NZ_CP069173:5897-6166 [Klebsiella pneumoniae]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References