Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2690545..2690823 Replicon chromosome
Accession NZ_CP053640
Organism Staphylococcus aureus strain 14505

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag HA033_RS13345 Protein ID WP_001802298.1
Coordinates 2690545..2690649 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2690645..2690823 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA033_RS13330 2687342..2688124 + 783 WP_000908182.1 ABC transporter ATP-binding protein -
HA033_RS13335 2688192..2689049 + 858 WP_000370923.1 Cof-type HAD-IIB family hydrolase -
HA033_RS13340 2689707..2689865 - 159 WP_001792784.1 hypothetical protein -
HA033_RS13345 2690545..2690649 + 105 WP_001802298.1 hypothetical protein Toxin
- 2690645..2690823 - 179 - - Antitoxin
HA033_RS13350 2691082..2692173 - 1092 WP_000495669.1 hypothetical protein -
HA033_RS13355 2692439..2693416 - 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
HA033_RS13360 2693418..2693738 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
HA033_RS13365 2693890..2694555 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(20-71)


Sequences


Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T157319 WP_001802298.1 NZ_CP053640:2690545-2690649 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T157319 NZ_CP069133:c4569657-4569316 [Escherichia coli BW25113]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 179 bp

>AT157319 NZ_CP053640:c2690823-2690645 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9


Antitoxin

Download structure file

References