Detailed information of TA system TA157318

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2690545..2690807
• Replicon: chromosome
• Accession: NZ_CP053640
• Organism: Staphylococcus aureus strain 14505

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HA033_RS13345
• Protein ID: WP_001802298.1
• Coordinates: 2690545..2690649 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2690644..2690807 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA033_RS13330	2687342..2688124	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
HA033_RS13335	2688192..2689049	+	858	WP_000370923.1	Cof-type HAD-IIB family hydrolase	-
HA033_RS13340	2689707..2689865	-	159	WP_001792784.1	hypothetical protein	-
HA033_RS13345	2690545..2690649	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2690644..2690807	-	164	-	-	Antitoxin
HA033_RS13350	2691082..2692173	-	1092	WP_000495669.1	hypothetical protein	-
HA033_RS13355	2692439..2693416	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
HA033_RS13360	2693418..2693738	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HA033_RS13365	2693890..2694555	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T157318 WP_001802298.1 NZ_CP053640:2690545-2690649 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T157318 NZ_CP069133:c4523870-4523613 [Escherichia coli BW25113]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT157318 NZ_CP053640:c2690807-2690644 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin