Detailed information of TA system TA157317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2430693..2431210
• Replicon: chromosome
• Accession: NZ_CP053640
• Organism: Staphylococcus aureus strain 14505

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: HA033_RS11995
• Protein ID: WP_000113265.1
• Coordinates: 2430944..2431210 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: HA033_RS11990
• Protein ID: WP_000584499.1
• Coordinates: 2430693..2430944 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA033_RS11960	2426391..2427110	+	720	WP_000479576.1	amino acid ABC transporter permease	-
HA033_RS11965	2427107..2427838	+	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
HA033_RS11970	2427935..2429185	-	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
HA033_RS11975	2429440..2429802	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
HA033_RS11980	2429821..2430420	+	600	WP_000162810.1	DsbA family protein	-
HA033_RS11985	2430427..2430528	+	102	Protein_2328	hypothetical protein	-
HA033_RS11990	2430693..2430944	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HA033_RS11995	2430944..2431210	+	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
HA033_RS12000	2431245..2431316	+	72	Protein_2331	hypothetical protein	-
HA033_RS12005	2431505..2433052	+	1548	WP_000727772.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
HA033_RS12010	2433238..2433705	+	468	WP_000153347.1	SRPBCC domain-containing protein	-
HA033_RS12015	2433789..2433971	+	183	WP_000230292.1	hypothetical protein	-
HA033_RS12020	2434188..2435012	+	825	WP_000572038.1	formate/nitrite transporter family protein	-
HA033_RS12025	2435246..2435782	+	537	WP_000169317.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T157317 WP_000113265.1 NZ_CP053640:2430944-2431210 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T157317 NZ_CP069133:4438509-4438859 [Escherichia coli BW25113]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT157317 WP_000584499.1 NZ_CP053640:2430693-2430944 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT157317 NZ_CP069133:4438264-4438515 [Escherichia coli BW25113]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60