Detailed information of TA system TA157315

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2405488..2405672
• Replicon: chromosome
• Accession: NZ_CP053640
• Organism: Staphylococcus aureus strain 14505

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: HA033_RS11860
• Protein ID: WP_000482652.1
• Coordinates: 2405488..2405595 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2405612..2405672 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA033_RS11835	2400850..2401323	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
HA033_RS11840	2401446..2402657	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
HA033_RS11845	2402839..2403498	-	660	WP_000831298.1	membrane protein	-
HA033_RS11850	2403558..2404700	-	1143	WP_001176863.1	glycerate kinase	-
HA033_RS11855	2404968..2405354	+	387	WP_000779360.1	flippase GtxA	-
HA033_RS11860	2405488..2405595	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2405612..2405672	-	61	-	-	Antitoxin
HA033_RS11865	2406298..2408061	+	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
HA033_RS11870	2408086..2409819	+	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
HA033_RS11875	2410050..2410217	+	168	Protein_2306	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T157315 WP_000482652.1 NZ_CP053640:2405488-2405595 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T157315 NZ_CP069133:c3693447-3693340 [Escherichia coli BW25113]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT157315 NZ_CP053640:c2405672-2405612 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin