Detailed information of TA system TA157304

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18809..19147
• Replicon: chromosome
• Accession: NZ_CP053640
• Organism: Staphylococcus aureus strain 14505

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: HA033_RS00100
• Protein ID: WP_011447039.1
• Coordinates: 18809..18985 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	18973..19147 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA033_RS00080	14044..17829	+	3786	WP_000582154.1	hypothetical protein	-
HA033_RS00085	17819..17971	+	153	WP_001153681.1	hypothetical protein	-
HA033_RS00090	18018..18305	+	288	WP_001040261.1	hypothetical protein	-
HA033_RS00095	18363..18659	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
HA033_RS00100	18809..18985	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	18973..19147	-	175	-	-	Antitoxin
HA033_RS00110	19197..19451	+	255	WP_000611512.1	phage holin	-
HA033_RS00115	19463..20218	+	756	WP_000861038.1	CHAP domain-containing protein	-
HA033_RS00120	20409..20900	+	492	WP_000919350.1	staphylokinase	-
HA033_RS00125	21550..21885	+	336	Protein_24	SH3 domain-containing protein	-
HA033_RS00130	21980..22429	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
HA033_RS00135	23114..23464	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
HA033_RS00140	23517..23777	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	1..23464	23463

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T157304 WP_011447039.1 NZ_CP053640:18809-18985 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T157304 NZ_CP069133:c1917464-1917361 [Escherichia coli BW25113]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 175 bp

>AT157304 NZ_CP053640:c19147-18973 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin