Detailed information of TA system TA157298

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2625381..2625563
• Replicon: chromosome
• Accession: NZ_CP053639
• Organism: Staphylococcus aureus strain 14732

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: HA036_RS13030
• Protein ID: WP_001801861.1
• Coordinates: 2625381..2625476 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2625504..2625563 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA036_RS12990	2621041..2621667	+	627	WP_000669046.1	hypothetical protein	-
HA036_RS12995	2621708..2622052	+	345	WP_000627551.1	DUF3969 family protein	-
HA036_RS13000	2622150..2622701	+	552	WP_000414205.1	hypothetical protein	-
HA036_RS13005	2622919..2623560	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
HA036_RS13010	2623674..2623859	-	186	WP_000809857.1	hypothetical protein	-
HA036_RS13015	2623861..2624037	-	177	WP_000375476.1	hypothetical protein	-
HA036_RS13020	2624048..2624431	-	384	WP_000070811.1	hypothetical protein	-
HA036_RS13025	2625035..2625178	-	144	WP_001549059.1	transposase	-
HA036_RS13030	2625381..2625476	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2625504..2625563	-	60	-	-	Antitoxin
HA036_RS13035	2625599..2625700	+	102	WP_001791893.1	hypothetical protein	-
HA036_RS13040	2625678..2625854	-	177	Protein_2531	transposase	-
HA036_RS13045	2626048..2626425	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2620343..2620828	485

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T157298 WP_001801861.1 NZ_CP053639:2625381-2625476 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T157298 NZ_CP069133:c1265266-1265159 [Escherichia coli BW25113]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT157298 NZ_CP053639:c2625563-2625504 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin