Detailed information of TA system TA157294

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 413226..413410
• Replicon: chromosome
• Accession: NZ_CP053639
• Organism: Staphylococcus aureus strain 14732

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: HA036_RS02315
• Protein ID: WP_000482650.1
• Coordinates: 413303..413410 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	413226..413286 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA036_RS02300	408756..408923	-	168	WP_001789936.1	hypothetical protein	-
HA036_RS02305	409154..410887	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
HA036_RS02310	410912..412675	-	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
-	413226..413286	+	61	-	-	Antitoxin
HA036_RS02315	413303..413410	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
HA036_RS02320	413544..413930	-	387	WP_000779358.1	flippase GtxA	-
HA036_RS02325	414198..415340	+	1143	WP_001176863.1	glycerate kinase	-
HA036_RS02330	415400..416059	+	660	WP_000831298.1	membrane protein	-
HA036_RS02335	416241..417452	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
HA036_RS02340	417575..418048	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T157294 WP_000482650.1 NZ_CP053639:c413410-413303 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T157294 NZ_CP069133:248788-249186 [Escherichia coli BW25113]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT157294 NZ_CP053639:413226-413286 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin