Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 387873..388390 Replicon chromosome
Accession NZ_CP053639
Organism Staphylococcus aureus strain 14732

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag HA036_RS02180 Protein ID WP_000113262.1
Coordinates 387873..388139 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag HA036_RS02185 Protein ID WP_000584499.1
Coordinates 388139..388390 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA036_RS02150 383299..383835 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
HA036_RS02155 384068..384892 - 825 WP_000572040.1 formate/nitrite transporter family protein -
HA036_RS02160 385109..385291 - 183 WP_000230294.1 hypothetical protein -
HA036_RS02165 385375..385842 - 468 WP_000153344.1 SRPBCC domain-containing protein -
HA036_RS02170 386028..387578 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HA036_RS02175 387767..387838 - 72 Protein_387 hypothetical protein -
HA036_RS02180 387873..388139 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
HA036_RS02185 388139..388390 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HA036_RS02190 388555..388656 - 102 WP_031806924.1 hypothetical protein -
HA036_RS02195 388663..389262 - 600 WP_000162813.1 DsbA family protein -
HA036_RS02200 389281..389643 - 363 WP_000819843.1 DUF4467 domain-containing protein -
HA036_RS02205 389899..391149 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
HA036_RS02210 391246..391977 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
HA036_RS02215 391974..392693 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T157293 WP_000113262.1 NZ_CP053639:c388139-387873 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T157293 NZ_CP069133:c242726-242448 [Escherichia coli BW25113]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT157293 WP_000584499.1 NZ_CP053639:c388390-388139 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT157293 NZ_CP069133:c242989-242729 [Escherichia coli BW25113]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References