Detailed information of TA system TA157291

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 122871..123134
• Replicon: chromosome
• Accession: NZ_CP053639
• Organism: Staphylococcus aureus strain 14732

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HA036_RS00795
• Protein ID: WP_001802298.1
• Coordinates: 123030..123134 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	122871..123035 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA036_RS00775	119111..119776	-	666	WP_001024094.1	SDR family oxidoreductase	-
HA036_RS00780	119928..120248	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HA036_RS00785	120250..121230	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
HA036_RS00790	121496..122587	+	1092	WP_000495671.1	lytic regulatory protein	-
-	122871..123035	+	165	-	-	Antitoxin
HA036_RS00795	123030..123134	-	105	WP_001802298.1	hypothetical protein	Toxin
HA036_RS00800	123295..123778	-	484	Protein_121	recombinase family protein	-
HA036_RS00805	123821..124957	-	1137	WP_000115564.1	SAP domain-containing protein	-
HA036_RS00810	125246..125338	+	93	WP_001790138.1	hypothetical protein	-
HA036_RS00815	126043..126900	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
HA036_RS00820	126968..127750	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T157291 WP_001802298.1 NZ_CP053639:c123134-123030 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T157291 NZ_CP069132:c4523866-4523609 [Escherichia coli BW25113]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT157291 NZ_CP053639:122871-123035 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin