Detailed information of TA system TA157284

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2679568..2679846
• Replicon: chromosome
• Accession: NZ_CP053636
• Organism: Staphylococcus aureus strain 14640

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HA037_RS13240
• Protein ID: WP_001802298.1
• Coordinates: 2679568..2679672 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2679668..2679846 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA037_RS13225	2676365..2677147	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
HA037_RS13230	2677215..2678072	+	858	WP_000370923.1	Cof-type HAD-IIB family hydrolase	-
HA037_RS13235	2678730..2678888	-	159	WP_001792784.1	hypothetical protein	-
HA037_RS13240	2679568..2679672	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2679668..2679846	-	179	-	-	Antitoxin
HA037_RS13245	2680048..2681139	-	1092	WP_000495669.1	hypothetical protein	-
HA037_RS13250	2681405..2682382	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
HA037_RS13255	2682384..2682704	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HA037_RS13260	2682856..2683521	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T157284 WP_001802298.1 NZ_CP053636:2679568-2679672 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T157284 NZ_CP069132:c3034178-3033771 [Escherichia coli BW25113]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT157284 NZ_CP053636:c2679846-2679668 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin