Detailed information of TA system TA157282

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2419700..2420217
• Replicon: chromosome
• Accession: NZ_CP053636
• Organism: Staphylococcus aureus strain 14640

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: HA037_RS11890
• Protein ID: WP_000113265.1
• Coordinates: 2419951..2420217 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: HA037_RS11885
• Protein ID: WP_000584499.1
• Coordinates: 2419700..2419951 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA037_RS11855	2415398..2416117	+	720	WP_000479576.1	amino acid ABC transporter permease	-
HA037_RS11860	2416114..2416845	+	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
HA037_RS11865	2416942..2418192	-	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
HA037_RS11870	2418447..2418809	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
HA037_RS11875	2418828..2419427	+	600	WP_000162810.1	DsbA family protein	-
HA037_RS11880	2419434..2419535	+	102	Protein_2310	hypothetical protein	-
HA037_RS11885	2419700..2419951	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HA037_RS11890	2419951..2420217	+	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
HA037_RS11895	2420252..2420323	+	72	Protein_2313	hypothetical protein	-
HA037_RS11900	2420512..2422059	+	1548	WP_000727772.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
HA037_RS11905	2422245..2422712	+	468	WP_000153347.1	SRPBCC domain-containing protein	-
HA037_RS11910	2422796..2422978	+	183	WP_000230292.1	hypothetical protein	-
HA037_RS11915	2423195..2424019	+	825	WP_000572038.1	formate/nitrite transporter family protein	-
HA037_RS11920	2424253..2424789	+	537	WP_000169317.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T157282 WP_000113265.1 NZ_CP053636:2419951-2420217 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T157282 NZ_CP069132:2770808-2771137 [Escherichia coli BW25113]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT157282 WP_000584499.1 NZ_CP053636:2419700-2419951 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT157282 NZ_CP069132:2770470-2770787 [Escherichia coli BW25113]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60