Detailed information of TA system TA157275

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1278787..1279366
• Replicon: chromosome
• Accession: NZ_CP053636
• Organism: Staphylococcus aureus strain 14640

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: HA037_RS06460
• Protein ID: WP_001025401.1
• Coordinates: 1279121..1279366 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1278787..1279152 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA037_RS06420	1275528..1276085	-	558	WP_000645045.1	DUF2815 family protein	-
HA037_RS06425	1276111..1277277	-	1167	WP_105799089.1	DUF2800 domain-containing protein	-
HA037_RS06430	1277274..1277636	-	363	WP_000985976.1	hypothetical protein	-
HA037_RS06435	1277651..1277974	-	324	WP_000174994.1	hypothetical protein	-
HA037_RS06440	1278053..1278214	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
HA037_RS06445	1278227..1278490	-	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
HA037_RS06450	1278517..1278732	-	216	WP_001097552.1	hypothetical protein	-
HA037_RS06455	1278787..1279152	+	366	WP_001128433.1	hypothetical protein	Antitoxin
HA037_RS06460	1279121..1279366	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
HA037_RS06465	1279433..1279813	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
HA037_RS06470	1279800..1279997	-	198	WP_001148860.1	hypothetical protein	-
HA037_RS06475	1280067..1280279	+	213	WP_000362644.1	hypothetical protein	-
HA037_RS06480	1280320..1280469	-	150	WP_000771849.1	hypothetical protein	-
HA037_RS06485	1280498..1281274	-	777	WP_001148544.1	Rha family transcriptional regulator	-
HA037_RS06490	1281288..1281524	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
HA037_RS06495	1281676..1281990	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
HA037_RS06500	1282003..1282464	+	462	WP_000525004.1	hypothetical protein	-
HA037_RS06505	1282492..1282713	+	222	Protein_1255	membrane lipoprotein lipid attachment site-containing protein	-
HA037_RS06510	1283007..1283891	+	885	WP_001025527.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1236998..1285401	48403

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T157275 WP_001025401.1 NZ_CP053636:c1279366-1279121 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T157275 NZ_CP069132:c1586429-1585107 [Escherichia coli BW25113]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT157275 NZ_CP053636:1278787-1279152 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin