Detailed information of TA system TA157259

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2270558..2270742
• Replicon: chromosome
• Accession: NZ_CP053634
• Organism: Staphylococcus aureus strain 14638

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: HA038_RS11205
• Protein ID: WP_000482652.1
• Coordinates: 2270558..2270665 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2270682..2270742 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA038_RS11180	2265920..2266393	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
HA038_RS11185	2266516..2267727	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
HA038_RS11190	2267909..2268568	-	660	WP_000831298.1	membrane protein	-
HA038_RS11195	2268628..2269770	-	1143	WP_001176863.1	glycerate kinase	-
HA038_RS11200	2270038..2270424	+	387	WP_000779360.1	flippase GtxA	-
HA038_RS11205	2270558..2270665	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2270682..2270742	-	61	-	-	Antitoxin
HA038_RS11210	2271368..2273131	+	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
HA038_RS11215	2273156..2274889	+	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
HA038_RS11220	2275120..2275287	+	168	Protein_2178	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T157259 WP_000482652.1 NZ_CP053634:2270558-2270665 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T157259 NZ_CP069084:c4559394-4559260 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT157259 NZ_CP053634:c2270742-2270682 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin