Detailed information of TA system TA157254

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1278782..1279361
• Replicon: chromosome
• Accession: NZ_CP053634
• Organism: Staphylococcus aureus strain 14638

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: HA038_RS06455
• Protein ID: WP_001025401.1
• Coordinates: 1279116..1279361 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1278782..1279147 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA038_RS06415	1275523..1276080	-	558	WP_000645045.1	DUF2815 family protein	-
HA038_RS06420	1276106..1277272	-	1167	WP_105799089.1	DUF2800 domain-containing protein	-
HA038_RS06425	1277269..1277631	-	363	WP_000985976.1	hypothetical protein	-
HA038_RS06430	1277646..1277969	-	324	WP_000174994.1	hypothetical protein	-
HA038_RS06435	1278048..1278209	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
HA038_RS06440	1278222..1278485	-	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
HA038_RS06445	1278512..1278727	-	216	WP_001097552.1	hypothetical protein	-
HA038_RS06450	1278782..1279147	+	366	WP_001128433.1	hypothetical protein	Antitoxin
HA038_RS06455	1279116..1279361	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
HA038_RS06460	1279428..1279808	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
HA038_RS06465	1279795..1279992	-	198	WP_001148860.1	hypothetical protein	-
HA038_RS06470	1280062..1280274	+	213	WP_000362644.1	hypothetical protein	-
HA038_RS06475	1280315..1280464	-	150	WP_000771849.1	hypothetical protein	-
HA038_RS06480	1280493..1281269	-	777	WP_001148544.1	Rha family transcriptional regulator	-
HA038_RS06485	1281283..1281519	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
HA038_RS06490	1281671..1281985	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
HA038_RS06495	1281998..1282459	+	462	WP_000525004.1	hypothetical protein	-
HA038_RS06500	1282487..1282708	+	222	Protein_1254	membrane lipoprotein lipid attachment site-containing protein	-
HA038_RS06505	1283002..1283886	+	885	WP_001025527.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1236993..1285396	48403

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T157254 WP_001025401.1 NZ_CP053634:c1279361-1279116 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T157254 NZ_CP069080:5679528-5679821 [Pseudomonas putida]
ATGTTTCTCGTTGAACAGACGGAAAGCTTTGCCGCTTGGCTATCGAGCTTGAGAGATTTGAGGGCCAGGCTGGCGATAGG
TCGTAGGCTGGAGCGAGCAGCGGCGGGCAATCTTGGTGACTTCAAGTGGCCTGGAGGCGGTATTGGTGAGCTTCGCATCG
ACGTAGCTGCCGGTTATCGCGTCTATTTCACGCAAAAGGGGCAGAGGTTGGTTTTACTGCTGGTCGGCGGCGACAAGTCC
ACCCAAGCCGCCGACATCCTCAACGCCAGAAAGCTGCTGAAGGAGATGAAATGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT157254 NZ_CP053634:1278782-1279147 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin