Detailed information of TA system TA157245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 1455224..1455756
• Replicon: chromosome
• Accession: NZ_CP053627
• Organism: Xylella taiwanensis strain PLS229

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: Z9JHK5
• Locus tag: PLS229_RS06330
• Protein ID: WP_038272512.1
• Coordinates: 1455224..1455496 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Z9JHR3
• Locus tag: PLS229_RS06335
• Protein ID: WP_038272513.1
• Coordinates: 1455496..1455756 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLS229_RS06280	1451461..1451685	-	225	WP_081755494.1	hypothetical protein	-
PLS229_RS06285	1451706..1451912	-	207	WP_038273075.1	hypothetical protein	-
PLS229_RS06290	1451915..1452232	-	318	WP_051482395.1	hypothetical protein	-
PLS229_RS06295	1452505..1453092	-	588	WP_038273076.1	hypothetical protein	-
PLS229_RS06300	1453289..1453432	-	144	WP_160165233.1	hypothetical protein	-
PLS229_RS06305	1453552..1453752	-	201	WP_038273077.1	hypothetical protein	-
PLS229_RS06310	1453801..1454064	-	264	WP_162814095.1	hypothetical protein	-
PLS229_RS06315	1454068..1454229	-	162	WP_160165182.1	hypothetical protein	-
PLS229_RS06320	1454318..1454785	+	468	WP_162814096.1	helix-turn-helix domain-containing protein	-
PLS229_RS06325	1454844..1455188	+	345	WP_038272511.1	hypothetical protein	-
PLS229_RS06330	1455224..1455496	-	273	WP_038272512.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
PLS229_RS06335	1455496..1455756	-	261	WP_038272513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
PLS229_RS06340	1455845..1456972	-	1128	WP_114867127.1	hypothetical protein	-
PLS229_RS06345	1456985..1457329	-	345	WP_038273069.1	DUF2523 domain-containing protein	-
PLS229_RS06350	1457332..1458801	-	1470	Protein_1230	hypothetical protein	-
PLS229_RS06355	1458897..1459121	-	225	WP_081755494.1	hypothetical protein	-
PLS229_RS06360	1459142..1459348	-	207	WP_038273075.1	hypothetical protein	-
PLS229_RS06365	1459351..1459668	-	318	WP_051482395.1	hypothetical protein	-
PLS229_RS06370	1459941..1460528	-	588	WP_038273076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1447227..1476393	29166

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10638.26 Da
• Isoelectric Point: 9.9110

>T157245 WP_038272512.1 NZ_CP053627:c1455496-1455224 [Xylella taiwanensis]
MRRPAYSSQFKRDVRVSQKRGKDIEKLKILITLLIEGSPLPAMYLDHPLKGQWRSFRDAHVEPDWLLIYKVDGDVVRFER
TGRHADLFDD

Nucleotide

• Length: 273 bp

>T157245 NZ_CP069078:c3794936-3794544 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9440.91 Da
• Isoelectric Point: 4.8047

>AT157245 WP_038272513.1 NZ_CP053627:c1455756-1455496 [Xylella taiwanensis]
MAANALVRARVDEALKDEAASVLATMGLTVSDLIRITLTKVAREKMLPFEMHSPNRLTVETFVKSECGEDVHYAESADAM
FKDLGI

Nucleotide

• Length: 261 bp

>AT157245 NZ_CP069078:c3795211-3794936 [Mycobacterium tuberculosis]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Structures

Toxin

• AlphaFold DB: Z9JHK5

Antitoxin

• AlphaFold DB: Z9JHR3