Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 740330..740873 Replicon chromosome
Accession NZ_CP053619
Organism Lacticaseibacillus rhamnosus strain LV108

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag HPC59_RS03465 Protein ID WP_005709630.1
Coordinates 740330..740617 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag HPC59_RS03470 Protein ID WP_005714439.1
Coordinates 740601..740873 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPC59_RS03435 735578..735946 - 369 WP_005686376.1 PTS-dependent dihydroxyacetone kinase phosphotransferase subunit DhaM -
HPC59_RS03440 735980..736561 - 582 WP_005709619.1 dihydroxyacetone kinase subunit L -
HPC59_RS03445 736548..737567 - 1020 WP_005709622.1 dihydroxyacetone kinase subunit DhaK -
HPC59_RS03450 737761..738189 - 429 WP_005714437.1 OsmC family protein -
HPC59_RS03455 738300..738479 - 180 WP_005709626.1 hypothetical protein -
HPC59_RS03460 738697..740106 - 1410 WP_005714438.1 3'-5' exonuclease -
HPC59_RS03465 740330..740617 - 288 WP_005709630.1 type II toxin-antitoxin system YafQ family toxin Toxin
HPC59_RS03470 740601..740873 - 273 WP_005714439.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPC59_RS03475 740987..741280 + 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
HPC59_RS03480 741362..742525 + 1164 WP_005709634.1 MFS transporter -
HPC59_RS03485 742688..744061 - 1374 WP_005714442.1 MFS transporter -
HPC59_RS03490 744174..745274 + 1101 WP_005709638.1 metalloregulator ArsR/SmtB family transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-67)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10888.77 Da        Isoelectric Point: 10.9032

>T157239 WP_005709630.1 NZ_CP053619:c740617-740330 [Lacticaseibacillus rhamnosus]
MMLTINRTRTFKRQFKHLLRQGKDMTKLATAIDTLQRQDRVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALIL
MLLATGTHRDTLNIE

Download         Length: 288 bp

>T157239 NZ_CP069078:c3131624-3131232 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10073.49 Da        Isoelectric Point: 5.1154

>AT157239 WP_005714439.1 NZ_CP053619:c740873-740601 [Lacticaseibacillus rhamnosus]
METKSRISVRIDTKTKERALHVLNSMGLDMSSAINMYLKRIGDTGELPFTPEMSFADQLQAAEADVKAGRTKSFKTVDAL
MKDLYNDVDD

Download         Length: 273 bp

>AT157239 NZ_CP069078:c3131836-3131621 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References