Detailed information of TA system TA157195

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3641527..3641749
• Replicon: chromosome
• Accession: NZ_CP053607
• Organism: Escherichia coli strain NEB5-alpha_F'Iq

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: HO392_RS17680
• Protein ID: WP_000141634.1
• Coordinates: 3641527..3641634 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3641683..3641749 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HO392_RS17655	3636780..3637532	-	753	Protein_3447	cellulose biosynthesis protein BcsQ	-
HO392_RS17660	3637544..3637732	-	189	WP_001063318.1	YhjR family protein	-
HO392_RS17665	3638005..3639576	+	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
HO392_RS17670	3639573..3639764	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
HO392_RS17675	3639761..3641440	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
HO392_RS17680	3641527..3641634	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	3641683..3641749	+	67	-	-	Antitoxin
HO392_RS17685	3642110..3643381	+	1272	WP_001295225.1	transporter	-
HO392_RS17690	3643411..3644415	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
HO392_RS17695	3644412..3645395	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
HO392_RS17700	3645406..3646308	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T157195 WP_000141634.1 NZ_CP053607:c3641634-3641527 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T157195 NZ_CP069078:c688981-688589 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT157195 NZ_CP053607:3641683-3641749 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin