Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1167981..1168203 Replicon chromosome
Accession NZ_CP053607
Organism Escherichia coli strain NEB5-alpha_F'Iq

Toxin (Protein)


Gene name ldrD Uniprot ID D3H2K1
Locus tag HO392_RS05665 Protein ID WP_000170955.1
Coordinates 1167981..1168088 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1168136..1168203 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO392_RS05635 1163837..1164670 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
HO392_RS05640 1164667..1165059 + 393 WP_000200374.1 invasion regulator SirB2 -
HO392_RS05645 1165063..1165872 + 810 WP_001257044.1 invasion regulator SirB1 -
HO392_RS05650 1165908..1166762 + 855 WP_046613400.1 3-deoxy-8-phosphooctulonate synthase -
HO392_RS05655 1166911..1167018 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
- 1167066..1167132 + 67 NuclAT_34 - -
- 1167066..1167132 + 67 NuclAT_34 - -
- 1167066..1167132 + 67 NuclAT_34 - -
- 1167066..1167132 + 67 NuclAT_34 - -
- 1167066..1167132 + 67 NuclAT_36 - -
- 1167066..1167132 + 67 NuclAT_36 - -
- 1167066..1167132 + 67 NuclAT_36 - -
- 1167066..1167132 + 67 NuclAT_36 - -
- 1167066..1167132 + 67 NuclAT_38 - -
- 1167066..1167132 + 67 NuclAT_38 - -
- 1167066..1167132 + 67 NuclAT_38 - -
- 1167066..1167132 + 67 NuclAT_38 - -
- 1167066..1167132 + 67 NuclAT_40 - -
- 1167066..1167132 + 67 NuclAT_40 - -
- 1167066..1167132 + 67 NuclAT_40 - -
- 1167066..1167132 + 67 NuclAT_40 - -
- 1167066..1167132 + 67 NuclAT_42 - -
- 1167066..1167132 + 67 NuclAT_42 - -
- 1167066..1167132 + 67 NuclAT_42 - -
- 1167066..1167132 + 67 NuclAT_42 - -
- 1167066..1167132 + 67 NuclAT_44 - -
- 1167066..1167132 + 67 NuclAT_44 - -
- 1167066..1167132 + 67 NuclAT_44 - -
- 1167066..1167132 + 67 NuclAT_44 - -
- 1167068..1167133 + 66 NuclAT_18 - -
- 1167068..1167133 + 66 NuclAT_18 - -
- 1167068..1167133 + 66 NuclAT_18 - -
- 1167068..1167133 + 66 NuclAT_18 - -
- 1167068..1167133 + 66 NuclAT_21 - -
- 1167068..1167133 + 66 NuclAT_21 - -
- 1167068..1167133 + 66 NuclAT_21 - -
- 1167068..1167133 + 66 NuclAT_21 - -
- 1167068..1167133 + 66 NuclAT_24 - -
- 1167068..1167133 + 66 NuclAT_24 - -
- 1167068..1167133 + 66 NuclAT_24 - -
- 1167068..1167133 + 66 NuclAT_24 - -
- 1167068..1167133 + 66 NuclAT_27 - -
- 1167068..1167133 + 66 NuclAT_27 - -
- 1167068..1167133 + 66 NuclAT_27 - -
- 1167068..1167133 + 66 NuclAT_27 - -
- 1167068..1167133 + 66 NuclAT_30 - -
- 1167068..1167133 + 66 NuclAT_30 - -
- 1167068..1167133 + 66 NuclAT_30 - -
- 1167068..1167133 + 66 NuclAT_30 - -
- 1167068..1167133 + 66 NuclAT_33 - -
- 1167068..1167133 + 66 NuclAT_33 - -
- 1167068..1167133 + 66 NuclAT_33 - -
- 1167068..1167133 + 66 NuclAT_33 - -
HO392_RS05660 1167446..1167553 - 108 WP_000170963.1 small toxic polypeptide LdrB -
- 1167601..1167668 + 68 NuclAT_17 - -
- 1167601..1167668 + 68 NuclAT_17 - -
- 1167601..1167668 + 68 NuclAT_17 - -
- 1167601..1167668 + 68 NuclAT_17 - -
- 1167601..1167668 + 68 NuclAT_20 - -
- 1167601..1167668 + 68 NuclAT_20 - -
- 1167601..1167668 + 68 NuclAT_20 - -
- 1167601..1167668 + 68 NuclAT_20 - -
- 1167601..1167668 + 68 NuclAT_23 - -
- 1167601..1167668 + 68 NuclAT_23 - -
- 1167601..1167668 + 68 NuclAT_23 - -
- 1167601..1167668 + 68 NuclAT_23 - -
- 1167601..1167668 + 68 NuclAT_26 - -
- 1167601..1167668 + 68 NuclAT_26 - -
- 1167601..1167668 + 68 NuclAT_26 - -
- 1167601..1167668 + 68 NuclAT_26 - -
- 1167601..1167668 + 68 NuclAT_29 - -
- 1167601..1167668 + 68 NuclAT_29 - -
- 1167601..1167668 + 68 NuclAT_29 - -
- 1167601..1167668 + 68 NuclAT_29 - -
- 1167601..1167668 + 68 NuclAT_32 - -
- 1167601..1167668 + 68 NuclAT_32 - -
- 1167601..1167668 + 68 NuclAT_32 - -
- 1167601..1167668 + 68 NuclAT_32 - -
- 1167602..1167667 + 66 NuclAT_35 - -
- 1167602..1167667 + 66 NuclAT_35 - -
- 1167602..1167667 + 66 NuclAT_35 - -
- 1167602..1167667 + 66 NuclAT_35 - -
- 1167602..1167667 + 66 NuclAT_37 - -
- 1167602..1167667 + 66 NuclAT_37 - -
- 1167602..1167667 + 66 NuclAT_37 - -
- 1167602..1167667 + 66 NuclAT_37 - -
- 1167602..1167667 + 66 NuclAT_39 - -
- 1167602..1167667 + 66 NuclAT_39 - -
- 1167602..1167667 + 66 NuclAT_39 - -
- 1167602..1167667 + 66 NuclAT_39 - -
- 1167602..1167667 + 66 NuclAT_41 - -
- 1167602..1167667 + 66 NuclAT_41 - -
- 1167602..1167667 + 66 NuclAT_41 - -
- 1167602..1167667 + 66 NuclAT_41 - -
- 1167602..1167667 + 66 NuclAT_43 - -
- 1167602..1167667 + 66 NuclAT_43 - -
- 1167602..1167667 + 66 NuclAT_43 - -
- 1167602..1167667 + 66 NuclAT_43 - -
- 1167602..1167667 + 66 NuclAT_45 - -
- 1167602..1167667 + 66 NuclAT_45 - -
- 1167602..1167667 + 66 NuclAT_45 - -
- 1167602..1167667 + 66 NuclAT_45 - -
HO392_RS05665 1167981..1168088 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC Toxin
- 1168136..1168203 + 68 NuclAT_16 - Antitoxin
- 1168136..1168203 + 68 NuclAT_16 - Antitoxin
- 1168136..1168203 + 68 NuclAT_16 - Antitoxin
- 1168136..1168203 + 68 NuclAT_16 - Antitoxin
- 1168136..1168203 + 68 NuclAT_19 - Antitoxin
- 1168136..1168203 + 68 NuclAT_19 - Antitoxin
- 1168136..1168203 + 68 NuclAT_19 - Antitoxin
- 1168136..1168203 + 68 NuclAT_19 - Antitoxin
- 1168136..1168203 + 68 NuclAT_22 - Antitoxin
- 1168136..1168203 + 68 NuclAT_22 - Antitoxin
- 1168136..1168203 + 68 NuclAT_22 - Antitoxin
- 1168136..1168203 + 68 NuclAT_22 - Antitoxin
- 1168136..1168203 + 68 NuclAT_25 - Antitoxin
- 1168136..1168203 + 68 NuclAT_25 - Antitoxin
- 1168136..1168203 + 68 NuclAT_25 - Antitoxin
- 1168136..1168203 + 68 NuclAT_25 - Antitoxin
- 1168136..1168203 + 68 NuclAT_28 - Antitoxin
- 1168136..1168203 + 68 NuclAT_28 - Antitoxin
- 1168136..1168203 + 68 NuclAT_28 - Antitoxin
- 1168136..1168203 + 68 NuclAT_28 - Antitoxin
- 1168136..1168203 + 68 NuclAT_31 - Antitoxin
- 1168136..1168203 + 68 NuclAT_31 - Antitoxin
- 1168136..1168203 + 68 NuclAT_31 - Antitoxin
- 1168136..1168203 + 68 NuclAT_31 - Antitoxin
HO392_RS05670 1168492..1169592 - 1101 WP_000063607.1 sodium-potassium/proton antiporter ChaA -
HO392_RS05675 1169862..1170092 + 231 WP_001146444.1 putative cation transport regulator ChaB -
HO392_RS05680 1170250..1170945 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
HO392_RS05685 1170989..1171342 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
HO392_RS05690 1171527..1172921 + 1395 WP_000086217.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4013.82 Da        Isoelectric Point: 11.4779

>T157168 WP_000170955.1 NZ_CP053607:c1168088-1167981 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T157168 NZ_CP069077:c2385896-2385462 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 68 bp

>AT157168 NZ_CP053607:1168136-1168203 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J2A9

Antitoxin

Download structure file

References