Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3624547..3625240 Replicon chromosome
Accession NZ_CP053603
Organism Escherichia coli strain Dam/Dcm

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HO395_RS17525 Protein ID WP_000415584.1
Coordinates 3624547..3624843 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HO395_RS17530 Protein ID WP_000650107.1
Coordinates 3624845..3625240 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO395_RS17490 3619635..3619949 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
HO395_RS17495 3619980..3620561 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HO395_RS17500 3620880..3621212 + 333 WP_000917684.1 DUF2645 family protein -
HO395_RS17505 3621258..3622607 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
HO395_RS17510 3622604..3623263 - 660 WP_001221495.1 two-component system response regulator QseB -
HO395_RS17515 3623415..3623807 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HO395_RS17520 3623860..3624342 + 483 WP_000183505.1 transcriptional regulator -
HO395_RS17525 3624547..3624843 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HO395_RS17530 3624845..3625240 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HO395_RS17535 3625373..3626980 + 1608 WP_133412436.1 ABC transporter substrate-binding protein -
HO395_RS17540 3627118..3629376 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T157084 WP_000415584.1 NZ_CP053603:3624547-3624843 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T157084 NZ_CP069076:c750363-749980 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT157084 WP_000650107.1 NZ_CP053603:3624845-3625240 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT157084 NZ_CP069076:c750613-750458 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References