Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1255484..1255706 Replicon chromosome
Accession NZ_CP053603
Organism Escherichia coli strain Dam/Dcm

Toxin (Protein)


Gene name ldrD Uniprot ID D3H2K1
Locus tag HO395_RS06060 Protein ID WP_000170955.1
Coordinates 1255484..1255591 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1255639..1255706 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO395_RS06030 1251340..1252173 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
HO395_RS06035 1252170..1252562 + 393 WP_000200374.1 invasion regulator SirB2 -
HO395_RS06040 1252566..1253375 + 810 WP_001257044.1 invasion regulator SirB1 -
HO395_RS06045 1253411..1254265 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
HO395_RS06050 1254414..1254521 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
- 1254569..1254635 + 67 NuclAT_34 - -
- 1254569..1254635 + 67 NuclAT_34 - -
- 1254569..1254635 + 67 NuclAT_34 - -
- 1254569..1254635 + 67 NuclAT_34 - -
- 1254569..1254635 + 67 NuclAT_36 - -
- 1254569..1254635 + 67 NuclAT_36 - -
- 1254569..1254635 + 67 NuclAT_36 - -
- 1254569..1254635 + 67 NuclAT_36 - -
- 1254569..1254635 + 67 NuclAT_38 - -
- 1254569..1254635 + 67 NuclAT_38 - -
- 1254569..1254635 + 67 NuclAT_38 - -
- 1254569..1254635 + 67 NuclAT_38 - -
- 1254569..1254635 + 67 NuclAT_40 - -
- 1254569..1254635 + 67 NuclAT_40 - -
- 1254569..1254635 + 67 NuclAT_40 - -
- 1254569..1254635 + 67 NuclAT_40 - -
- 1254569..1254635 + 67 NuclAT_42 - -
- 1254569..1254635 + 67 NuclAT_42 - -
- 1254569..1254635 + 67 NuclAT_42 - -
- 1254569..1254635 + 67 NuclAT_42 - -
- 1254569..1254635 + 67 NuclAT_44 - -
- 1254569..1254635 + 67 NuclAT_44 - -
- 1254569..1254635 + 67 NuclAT_44 - -
- 1254569..1254635 + 67 NuclAT_44 - -
- 1254571..1254636 + 66 NuclAT_18 - -
- 1254571..1254636 + 66 NuclAT_18 - -
- 1254571..1254636 + 66 NuclAT_18 - -
- 1254571..1254636 + 66 NuclAT_18 - -
- 1254571..1254636 + 66 NuclAT_21 - -
- 1254571..1254636 + 66 NuclAT_21 - -
- 1254571..1254636 + 66 NuclAT_21 - -
- 1254571..1254636 + 66 NuclAT_21 - -
- 1254571..1254636 + 66 NuclAT_24 - -
- 1254571..1254636 + 66 NuclAT_24 - -
- 1254571..1254636 + 66 NuclAT_24 - -
- 1254571..1254636 + 66 NuclAT_24 - -
- 1254571..1254636 + 66 NuclAT_27 - -
- 1254571..1254636 + 66 NuclAT_27 - -
- 1254571..1254636 + 66 NuclAT_27 - -
- 1254571..1254636 + 66 NuclAT_27 - -
- 1254571..1254636 + 66 NuclAT_30 - -
- 1254571..1254636 + 66 NuclAT_30 - -
- 1254571..1254636 + 66 NuclAT_30 - -
- 1254571..1254636 + 66 NuclAT_30 - -
- 1254571..1254636 + 66 NuclAT_33 - -
- 1254571..1254636 + 66 NuclAT_33 - -
- 1254571..1254636 + 66 NuclAT_33 - -
- 1254571..1254636 + 66 NuclAT_33 - -
HO395_RS06055 1254949..1255056 - 108 WP_000170963.1 small toxic polypeptide LdrB -
- 1255104..1255171 + 68 NuclAT_17 - -
- 1255104..1255171 + 68 NuclAT_17 - -
- 1255104..1255171 + 68 NuclAT_17 - -
- 1255104..1255171 + 68 NuclAT_17 - -
- 1255104..1255171 + 68 NuclAT_20 - -
- 1255104..1255171 + 68 NuclAT_20 - -
- 1255104..1255171 + 68 NuclAT_20 - -
- 1255104..1255171 + 68 NuclAT_20 - -
- 1255104..1255171 + 68 NuclAT_23 - -
- 1255104..1255171 + 68 NuclAT_23 - -
- 1255104..1255171 + 68 NuclAT_23 - -
- 1255104..1255171 + 68 NuclAT_23 - -
- 1255104..1255171 + 68 NuclAT_26 - -
- 1255104..1255171 + 68 NuclAT_26 - -
- 1255104..1255171 + 68 NuclAT_26 - -
- 1255104..1255171 + 68 NuclAT_26 - -
- 1255104..1255171 + 68 NuclAT_29 - -
- 1255104..1255171 + 68 NuclAT_29 - -
- 1255104..1255171 + 68 NuclAT_29 - -
- 1255104..1255171 + 68 NuclAT_29 - -
- 1255104..1255171 + 68 NuclAT_32 - -
- 1255104..1255171 + 68 NuclAT_32 - -
- 1255104..1255171 + 68 NuclAT_32 - -
- 1255104..1255171 + 68 NuclAT_32 - -
- 1255105..1255170 + 66 NuclAT_35 - -
- 1255105..1255170 + 66 NuclAT_35 - -
- 1255105..1255170 + 66 NuclAT_35 - -
- 1255105..1255170 + 66 NuclAT_35 - -
- 1255105..1255170 + 66 NuclAT_37 - -
- 1255105..1255170 + 66 NuclAT_37 - -
- 1255105..1255170 + 66 NuclAT_37 - -
- 1255105..1255170 + 66 NuclAT_37 - -
- 1255105..1255170 + 66 NuclAT_39 - -
- 1255105..1255170 + 66 NuclAT_39 - -
- 1255105..1255170 + 66 NuclAT_39 - -
- 1255105..1255170 + 66 NuclAT_39 - -
- 1255105..1255170 + 66 NuclAT_41 - -
- 1255105..1255170 + 66 NuclAT_41 - -
- 1255105..1255170 + 66 NuclAT_41 - -
- 1255105..1255170 + 66 NuclAT_41 - -
- 1255105..1255170 + 66 NuclAT_43 - -
- 1255105..1255170 + 66 NuclAT_43 - -
- 1255105..1255170 + 66 NuclAT_43 - -
- 1255105..1255170 + 66 NuclAT_43 - -
- 1255105..1255170 + 66 NuclAT_45 - -
- 1255105..1255170 + 66 NuclAT_45 - -
- 1255105..1255170 + 66 NuclAT_45 - -
- 1255105..1255170 + 66 NuclAT_45 - -
HO395_RS06060 1255484..1255591 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC Toxin
- 1255639..1255706 + 68 NuclAT_16 - Antitoxin
- 1255639..1255706 + 68 NuclAT_16 - Antitoxin
- 1255639..1255706 + 68 NuclAT_16 - Antitoxin
- 1255639..1255706 + 68 NuclAT_16 - Antitoxin
- 1255639..1255706 + 68 NuclAT_19 - Antitoxin
- 1255639..1255706 + 68 NuclAT_19 - Antitoxin
- 1255639..1255706 + 68 NuclAT_19 - Antitoxin
- 1255639..1255706 + 68 NuclAT_19 - Antitoxin
- 1255639..1255706 + 68 NuclAT_22 - Antitoxin
- 1255639..1255706 + 68 NuclAT_22 - Antitoxin
- 1255639..1255706 + 68 NuclAT_22 - Antitoxin
- 1255639..1255706 + 68 NuclAT_22 - Antitoxin
- 1255639..1255706 + 68 NuclAT_25 - Antitoxin
- 1255639..1255706 + 68 NuclAT_25 - Antitoxin
- 1255639..1255706 + 68 NuclAT_25 - Antitoxin
- 1255639..1255706 + 68 NuclAT_25 - Antitoxin
- 1255639..1255706 + 68 NuclAT_28 - Antitoxin
- 1255639..1255706 + 68 NuclAT_28 - Antitoxin
- 1255639..1255706 + 68 NuclAT_28 - Antitoxin
- 1255639..1255706 + 68 NuclAT_28 - Antitoxin
- 1255639..1255706 + 68 NuclAT_31 - Antitoxin
- 1255639..1255706 + 68 NuclAT_31 - Antitoxin
- 1255639..1255706 + 68 NuclAT_31 - Antitoxin
- 1255639..1255706 + 68 NuclAT_31 - Antitoxin
HO395_RS06065 1255995..1257095 - 1101 WP_000063607.1 sodium-potassium/proton antiporter ChaA -
HO395_RS06070 1257365..1257595 + 231 WP_001146444.1 putative cation transport regulator ChaB -
HO395_RS06075 1257753..1258448 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
HO395_RS06080 1258492..1258845 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
HO395_RS06085 1259030..1260424 + 1395 WP_000086217.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4013.82 Da        Isoelectric Point: 11.4779

>T157056 WP_000170955.1 NZ_CP053603:c1255591-1255484 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T157056 NZ_CP069075:c2877248-2876853 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 68 bp

>AT157056 NZ_CP053603:1255639-1255706 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J2A9

Antitoxin

Download structure file

References