156913

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1421402..1422095 Replicon chromosome
Accession NZ_CP053594
Organism Escherichia coli strain T7Express_Crystal

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HO402_RS06745 Protein ID WP_000415584.1
Coordinates 1421402..1421698 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HO402_RS06750 Protein ID WP_000650107.1
Coordinates 1421700..1422095 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO402_RS06710 1416490..1416804 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
HO402_RS06715 1416835..1417416 - 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
HO402_RS06720 1417735..1418067 + 333 WP_000917684.1 DUF2645 family protein -
HO402_RS06725 1418113..1419462 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
HO402_RS06730 1419459..1420118 - 660 WP_001221493.1 two-component system response regulator QseB -
HO402_RS06735 1420270..1420662 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HO402_RS06740 1420715..1421197 + 483 WP_000183505.1 transcriptional regulator -
HO402_RS06745 1421402..1421698 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HO402_RS06750 1421700..1422095 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HO402_RS06755 1422228..1423835 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HO402_RS06760 1423973..1426231 + 2259 WP_001281877.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T156913 WP_000415584.1 NZ_CP053594:1421402-1421698 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T156913 NZ_CP069073:1020615-1021049 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT156913 WP_000650107.1 NZ_CP053594:1421700-1422095 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT156913 NZ_CP069073:1020430-1020609 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References