Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1421758..1422451 Replicon chromosome
Accession NZ_CP053592
Organism Escherichia coli strain NEBExpress_Iq

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HO403_RS06750 Protein ID WP_000415584.1
Coordinates 1421758..1422054 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HO403_RS06755 Protein ID WP_000650107.1
Coordinates 1422056..1422451 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO403_RS06715 1416846..1417160 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
HO403_RS06720 1417191..1417772 - 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
HO403_RS06725 1418091..1418423 + 333 WP_000917684.1 DUF2645 family protein -
HO403_RS06730 1418469..1419818 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
HO403_RS06735 1419815..1420474 - 660 WP_001221493.1 two-component system response regulator QseB -
HO403_RS06740 1420626..1421018 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HO403_RS06745 1421071..1421553 + 483 WP_000183505.1 transcriptional regulator -
HO403_RS06750 1421758..1422054 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HO403_RS06755 1422056..1422451 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HO403_RS06760 1422584..1424191 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HO403_RS06765 1424329..1426587 + 2259 WP_001281877.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T156893 WP_000415584.1 NZ_CP053592:1421758-1422054 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T156893 NZ_CP069072:3754006-3754263 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT156893 WP_000650107.1 NZ_CP053592:1422056-1422451 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT156893 NZ_CP069072:3753734-3754009 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References