Detailed information of TA system TA156890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2462849..2463358
• Replicon: chromosome
• Accession: NZ_CP053590
• Organism: Aquimarina sp. TRL1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HN014_RS09920
• Protein ID: WP_176028725.1
• Coordinates: 2463098..2463358 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HN014_RS09915
• Protein ID: WP_176028724.1
• Coordinates: 2462849..2463097 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HN014_RS09910	2461719..2462318	+	600	WP_176028723.1	hypothetical protein	-
HN014_RS09915	2462849..2463097	+	249	WP_176028724.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HN014_RS09920	2463098..2463358	+	261	WP_176028725.1	Txe/YoeB family addiction module toxin	Toxin
HN014_RS09925	2463604..2464683	-	1080	WP_176028726.1	hypothetical protein	-
HN014_RS09930	2464978..2466396	-	1419	WP_176028727.1	cytochrome P450	-
HN014_RS09935	2467175..2467891	+	717	WP_176028728.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10403.09 Da
• Isoelectric Point: 9.7723

>T156890 WP_176028725.1 NZ_CP053590:2463098-2463358 [Aquimarina sp. TRL1]
MKLTWSISSWEDYLYWQKVDKKIVKRINELIKSCMRTPFEGIGKPEVLKGDLQGYWSRRITSEHRLVYKYENDQLLIAAC
RYHYGK

Nucleotide

• Length: 261 bp

>T156890 NZ_CP069072:3182466-3182909 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9515.84 Da
• Isoelectric Point: 4.8359

>AT156890 WP_176028724.1 NZ_CP053590:2462849-2463097 [Aquimarina sp. TRL1]
METVNYTEFRSNLKHWFDKVINDVSDIIIKRKNGKDLVLISLDEYNSLKETTYLLTGKNRDVLLNSIKELEAGNGIEKDL
IE

Nucleotide

• Length: 249 bp

>AT156890 NZ_CP069072:3182222-3182479 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA