Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 3298286..3298946 | Replicon | chromosome |
Accession | NZ_CP053572 | ||
Organism | Serratia marcescens strain S7.1 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | F0335_RS15830 | Protein ID | WP_149559135.1 |
Coordinates | 3298593..3298946 (-) | Length | 118 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A177IM12 |
Locus tag | F0335_RS15825 | Protein ID | WP_049200011.1 |
Coordinates | 3298286..3298588 (-) | Length | 101 a.a. |
Genomic Context
Location: 3295647..3296555 (909 bp)
Type: Others
Protein ID: WP_149559137.1
Type: Others
Protein ID: WP_149559137.1
Location: 3299384..3300679 (1296 bp)
Type: Others
Protein ID: WP_063989266.1
Type: Others
Protein ID: WP_063989266.1
Location: 3300707..3301513 (807 bp)
Type: Others
Protein ID: WP_107226504.1
Type: Others
Protein ID: WP_107226504.1
Location: 3293653..3294588 (936 bp)
Type: Others
Protein ID: WP_149559139.1
Type: Others
Protein ID: WP_149559139.1
Location: 3294588..3295508 (921 bp)
Type: Others
Protein ID: WP_149559138.1
Type: Others
Protein ID: WP_149559138.1
Location: 3296667..3297875 (1209 bp)
Type: Others
Protein ID: WP_149559136.1
Type: Others
Protein ID: WP_149559136.1
Location: 3298286..3298588 (303 bp)
Type: Antitoxin
Protein ID: WP_049200011.1
Type: Antitoxin
Protein ID: WP_049200011.1
Location: 3298593..3298946 (354 bp)
Type: Toxin
Protein ID: WP_149559135.1
Type: Toxin
Protein ID: WP_149559135.1
Location: 3301488..3302387 (900 bp)
Type: Others
Protein ID: WP_149559134.1
Type: Others
Protein ID: WP_149559134.1
Location: 3302480..3302845 (366 bp)
Type: Others
Protein ID: WP_060439472.1
Type: Others
Protein ID: WP_060439472.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F0335_RS15805 | 3293653..3294588 | - | 936 | WP_149559139.1 | alpha/beta hydrolase | - |
F0335_RS15810 | 3294588..3295508 | - | 921 | WP_149559138.1 | alpha/beta hydrolase | - |
F0335_RS15815 | 3295647..3296555 | + | 909 | WP_149559137.1 | LysR family transcriptional regulator | - |
F0335_RS15820 | 3296667..3297875 | - | 1209 | WP_149559136.1 | aldose 1-epimerase family protein | - |
F0335_RS15825 | 3298286..3298588 | - | 303 | WP_049200011.1 | XRE family transcriptional regulator | Antitoxin |
F0335_RS15830 | 3298593..3298946 | - | 354 | WP_149559135.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
F0335_RS15835 | 3299384..3300679 | + | 1296 | WP_063989266.1 | MFS transporter | - |
F0335_RS15840 | 3300707..3301513 | + | 807 | WP_107226504.1 | substrate-binding domain-containing protein | - |
F0335_RS15845 | 3301488..3302387 | - | 900 | WP_149559134.1 | LysR family transcriptional regulator | - |
F0335_RS15850 | 3302480..3302845 | - | 366 | WP_060439472.1 | diacylglycerol kinase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 118 a.a. Molecular weight: 13473.35 Da Isoelectric Point: 7.7808
>T156866 WP_149559135.1 NZ_CP053572:c3298946-3298593 [Serratia marcescens]
VWEIKTTDVFDDWFSSLNDADRAGVLAALMVLREKGSGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMLQIADREFTCWLNTLNEKE
VWEIKTTDVFDDWFSSLNDADRAGVLAALMVLREKGSGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMLQIADREFTCWLNTLNEKE
Download Length: 354 bp
>T156866 NZ_CP069072:1960219-1960467 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11017.82 Da Isoelectric Point: 5.7316
>AT156866 WP_049200011.1 NZ_CP053572:c3298588-3298286 [Serratia marcescens]
MGRTLEQLIADEKPEVVANAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEVVL
MGRTLEQLIADEKPEVVANAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEVVL
Download Length: 303 bp
>AT156866 NZ_CP069072:1960007-1960219 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
No matching records found |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A177IM12 |