Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3298286..3298946 Replicon chromosome
Accession NZ_CP053572
Organism Serratia marcescens strain S7.1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F0335_RS15830 Protein ID WP_149559135.1
Coordinates 3298593..3298946 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A177IM12
Locus tag F0335_RS15825 Protein ID WP_049200011.1
Coordinates 3298286..3298588 (-) Length 101 a.a.

Genomic Context


F0335_RS15815F0335_RS15835F0335_RS15840F0335_RS15805F0335_RS15810F0335_RS15820F0335_RS15825F0335_RS15830F0335_RS15845F0335_RS15850
Location: 3295647..3296555 (909 bp)
Type: Others
Protein ID: WP_149559137.1
Location: 3299384..3300679 (1296 bp)
Type: Others
Protein ID: WP_063989266.1
Location: 3300707..3301513 (807 bp)
Type: Others
Protein ID: WP_107226504.1
Location: 3293653..3294588 (936 bp)
Type: Others
Protein ID: WP_149559139.1
Location: 3294588..3295508 (921 bp)
Type: Others
Protein ID: WP_149559138.1
Location: 3296667..3297875 (1209 bp)
Type: Others
Protein ID: WP_149559136.1
Location: 3298286..3298588 (303 bp)
Type: Antitoxin
Protein ID: WP_049200011.1
Location: 3298593..3298946 (354 bp)
Type: Toxin
Protein ID: WP_149559135.1
Location: 3301488..3302387 (900 bp)
Type: Others
Protein ID: WP_149559134.1
Location: 3302480..3302845 (366 bp)
Type: Others
Protein ID: WP_060439472.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
F0335_RS158053293653..3294588-936WP_149559139.1alpha/beta hydrolase-
F0335_RS158103294588..3295508-921WP_149559138.1alpha/beta hydrolase-
F0335_RS158153295647..3296555+909WP_149559137.1LysR family transcriptional regulator-
F0335_RS158203296667..3297875-1209WP_149559136.1aldose 1-epimerase family protein-
F0335_RS158253298286..3298588-303WP_049200011.1XRE family transcriptional regulatorAntitoxin
F0335_RS158303298593..3298946-354WP_149559135.1type II toxin-antitoxin system RelE/ParE family toxinToxin
F0335_RS158353299384..3300679+1296WP_063989266.1MFS transporter-
F0335_RS158403300707..3301513+807WP_107226504.1substrate-binding domain-containing protein-
F0335_RS158453301488..3302387-900WP_149559134.1LysR family transcriptional regulator-
F0335_RS158503302480..3302845-366WP_060439472.1diacylglycerol kinase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-106)

Antitoxin

(33-79)


Sequences


Toxin        


Download         Length: 118 a.a.        Molecular weight: 13473.35 Da        Isoelectric Point: 7.7808

>T156866 WP_149559135.1 NZ_CP053572:c3298946-3298593 [Serratia marcescens]
VWEIKTTDVFDDWFSSLNDADRAGVLAALMVLREKGSGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMLQIADREFTCWLNTLNEKE

Download         Length: 354 bp

>T156866 NZ_CP069072:1960219-1960467 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11017.82 Da        Isoelectric Point: 5.7316

>AT156866 WP_049200011.1 NZ_CP053572:c3298588-3298286 [Serratia marcescens]
MGRTLEQLIADEKPEVVANAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEVVL

Download         Length: 303 bp

>AT156866 NZ_CP069072:1960007-1960219 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A177IM12

References