156843

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2098197..2098846 Replicon chromosome
Accession NZ_CP053568
Organism Enterobacter cloacae strain MY490

Toxin (Protein)


Gene name higB Uniprot ID A0A5E1A383
Locus tag HPB40_RS09920 Protein ID WP_013097692.1
Coordinates 2098484..2098846 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5E1A3P3
Locus tag HPB40_RS09915 Protein ID WP_013097693.1
Coordinates 2098197..2098496 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPB40_RS09905 (HPB40_09850) 2094607..2096580 + 1974 WP_013097695.1 PhoX family phosphatase -
HPB40_RS09910 (HPB40_09855) 2096683..2098071 + 1389 WP_013097694.1 phenylalanine transporter -
HPB40_RS09915 (HPB40_09860) 2098197..2098496 - 300 WP_013097693.1 helix-turn-helix transcriptional regulator Antitoxin
HPB40_RS09920 (HPB40_09865) 2098484..2098846 - 363 WP_013097692.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPB40_RS09925 (HPB40_09870) 2099051..2100289 + 1239 WP_013097691.1 MFS transporter -
HPB40_RS09930 (HPB40_09875) 2100305..2101330 + 1026 WP_013097690.1 sugar phosphate isomerase/epimerase -
HPB40_RS09935 (HPB40_09880) 2101323..2102465 + 1143 WP_013097689.1 Gfo/Idh/MocA family oxidoreductase -
HPB40_RS09940 (HPB40_09885) 2102541..2103512 + 972 WP_013097688.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13994.00 Da        Isoelectric Point: 7.3235

>T156843 WP_013097692.1 NZ_CP053568:c2098846-2098484 [Enterobacter cloacae]
MWNVETTDRFDEWFFEQTTALKEDVLAAMHILSEFGPQLGRPFVDTVKASAFGNMKELRIQHRGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYKEMIALADVEYHRHLANKEAIWQR

Download         Length: 363 bp

>T156843 NZ_CP069072:680582-680989 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10875.62 Da        Isoelectric Point: 8.6152

>AT156843 WP_013097693.1 NZ_CP053568:c2098496-2098197 [Enterobacter cloacae]
MATLKELMAQQSAESQERIAAKVEVMRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GELSIDVTLPNGKRIAFEI

Download         Length: 300 bp

>AT156843 NZ_CP069072:680370-680585 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1A383

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1A3P3

References