Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 316947..317442 Replicon chromosome
Accession NZ_CP053482
Organism Thiothrix sp. Ku-5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HMY34_RS01500 Protein ID WP_202719095.1
Coordinates 316947..317141 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HMY34_RS01505 Protein ID WP_202717404.1
Coordinates 317128..317442 (+) Length 105 a.a.

Genomic Context

HMY34_RS01480HMY34_RS01485HMY34_RS01500HMY34_RS01505HMY34_RS01510HMY34_RS01520HMY34_RS01475HMY34_RS01490HMY34_RS01495HMY34_RS01515HMY34_RS01525HMY34_RS01530
Location: 315216..315689 (474 bp)
Type: Others
Protein ID: WP_202717400.1
Location: 315692..315868 (177 bp)
Type: Others
Protein ID: WP_202717401.1
Location: 316947..317141 (195 bp)
Type: Toxin
Protein ID: WP_202719095.1
Location: 317128..317442 (315 bp)
Type: Antitoxin
Protein ID: WP_202717404.1
Location: 317769..318047 (279 bp)
Type: Others
Protein ID: WP_202717405.1
Location: 319048..320316 (1269 bp)
Type: Others
Protein ID: WP_202717407.1
Location: 314731..314952 (222 bp)
Type: Others
Protein ID: WP_202717399.1
Location: 315822..316427 (606 bp)
Type: Others
Protein ID: WP_202717402.1
Location: 316420..316671 (252 bp)
Type: Others
Protein ID: WP_202717403.1
Location: 318191..318892 (702 bp)
Type: Others
Protein ID: WP_202717406.1
Location: 320324..321448 (1125 bp)
Type: Others
Protein ID: WP_202717408.1
Location: 321611..321808 (198 bp)
Type: Others
Protein ID: WP_202717409.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HMY34_RS01475314731..314952-222WP_202717399.1hypothetical protein-
HMY34_RS01480315216..315689+474WP_202717400.1type II toxin-antitoxin system VapC family toxin-
HMY34_RS01485315692..315868+177WP_202717401.1hypothetical protein-
HMY34_RS01490315822..316427-606WP_202717402.1DUF3368 domain-containing protein-
HMY34_RS01495316420..316671-252WP_202717403.1UPF0175 family protein-
HMY34_RS01500316947..317141+195WP_202719095.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HMY34_RS01505317128..317442+315WP_202717404.1hypothetical proteinAntitoxin
HMY34_RS01510317769..318047+279WP_202717405.1type II toxin-antitoxin system prevent-host-death family antitoxin-
HMY34_RS01515318191..318892-702WP_202717406.1Crp/Fnr family transcriptional regulator-
HMY34_RS01520319048..320316+1269WP_202717407.1glucose-1-phosphate adenylyltransferase-
HMY34_RS01525320324..321448-1125WP_202717408.1GNAT family N-acetyltransferase-
HMY34_RS01530321611..321808-198WP_202717409.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(3-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7568.55 Da        Isoelectric Point: 9.6783

>T156813 WP_202719095.1 NZ_CP053482:316947-317141 [Thiothrix sp. Ku-5]
IEKSRVGIQGRGKRGGARVIYYYYDSFQSFYLLTIYAKNEMSDLTADQKHQLKTFVEVWRNEQA

Download         Length: 195 bp

>T156813 NZ_CP069071:c2226480-2226136 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11873.64 Da        Isoelectric Point: 10.4451

>AT156813 WP_202717404.1 NZ_CP053482:317128-317442 [Thiothrix sp. Ku-5]
MSKRNLFEELSTALVEAKQHSEGKLTLRTHVVQRAGVPEIKPQEILTIREMFNMSRGVFARHLHTSARTLESWEQGRTAP
NGQAVTLLRLVQRHPETLSYIAEL

Download         Length: 315 bp

>AT156813 NZ_CP069071:c2226722-2226474 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References