Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 316947..317442 Replicon chromosome
Accession NZ_CP053482
Organism Thiothrix sp. Ku-5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HMY34_RS01500 Protein ID WP_202719095.1
Coordinates 316947..317141 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HMY34_RS01505 Protein ID WP_202717404.1
Coordinates 317128..317442 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMY34_RS01475 314731..314952 - 222 WP_202717399.1 hypothetical protein -
HMY34_RS01480 315216..315689 + 474 WP_202717400.1 type II toxin-antitoxin system VapC family toxin -
HMY34_RS01485 315692..315868 + 177 WP_202717401.1 hypothetical protein -
HMY34_RS01490 315822..316427 - 606 WP_202717402.1 DUF3368 domain-containing protein -
HMY34_RS01495 316420..316671 - 252 WP_202717403.1 UPF0175 family protein -
HMY34_RS01500 316947..317141 + 195 WP_202719095.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HMY34_RS01505 317128..317442 + 315 WP_202717404.1 hypothetical protein Antitoxin
HMY34_RS01510 317769..318047 + 279 WP_202717405.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
HMY34_RS01515 318191..318892 - 702 WP_202717406.1 Crp/Fnr family transcriptional regulator -
HMY34_RS01520 319048..320316 + 1269 WP_202717407.1 glucose-1-phosphate adenylyltransferase -
HMY34_RS01525 320324..321448 - 1125 WP_202717408.1 GNAT family N-acetyltransferase -
HMY34_RS01530 321611..321808 - 198 WP_202717409.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(3-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7568.55 Da        Isoelectric Point: 9.6783

>T156813 WP_202719095.1 NZ_CP053482:316947-317141 [Thiothrix sp. Ku-5]
IEKSRVGIQGRGKRGGARVIYYYYDSFQSFYLLTIYAKNEMSDLTADQKHQLKTFVEVWRNEQA

Download         Length: 195 bp

>T156813 NZ_CP069071:c2226480-2226136 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11873.64 Da        Isoelectric Point: 10.4451

>AT156813 WP_202717404.1 NZ_CP053482:317128-317442 [Thiothrix sp. Ku-5]
MSKRNLFEELSTALVEAKQHSEGKLTLRTHVVQRAGVPEIKPQEILTIREMFNMSRGVFARHLHTSARTLESWEQGRTAP
NGQAVTLLRLVQRHPETLSYIAEL

Download         Length: 315 bp

>AT156813 NZ_CP069071:c2226722-2226474 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References