Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1604001..1604606 Replicon chromosome
Accession NZ_CP053417
Organism Salmonella bongori strain 92-0238

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CBX32_RS07210 Protein ID WP_171922653.1
Coordinates 1604295..1604606 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CBX32_RS07205 Protein ID WP_171922652.1
Coordinates 1604001..1604294 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBX32_RS07190 1601510..1602412 + 903 WP_000331357.1 formate dehydrogenase subunit beta -
CBX32_RS07195 1602409..1603044 + 636 WP_000829030.1 formate dehydrogenase cytochrome b556 subunit -
CBX32_RS07200 1603041..1603970 + 930 WP_020845723.1 formate dehydrogenase accessory protein FdhE -
CBX32_RS07205 1604001..1604294 - 294 WP_171922652.1 helix-turn-helix domain-containing protein Antitoxin
CBX32_RS07210 1604295..1604606 - 312 WP_171922653.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CBX32_RS07215 1604824..1605738 + 915 WP_079778186.1 alpha/beta hydrolase -
CBX32_RS07220 1605764..1606705 - 942 WP_171922654.1 fatty acid biosynthesis protein FabY -
CBX32_RS07225 1606750..1607187 - 438 WP_038393387.1 D-tyrosyl-tRNA(Tyr) deacylase -
CBX32_RS07230 1607184..1608056 - 873 WP_171922655.1 virulence factor BrkB family protein -
CBX32_RS07235 1608050..1608649 - 600 WP_000965694.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12342.27 Da        Isoelectric Point: 9.4460

>T156786 WP_171922653.1 NZ_CP053417:c1604606-1604295 [Salmonella bongori]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGSLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T156786 NZ_CP069071:c697187-696774 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10952.55 Da        Isoelectric Point: 10.8907

>AT156786 WP_171922652.1 NZ_CP053417:c1604294-1604001 [Salmonella bongori]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRSG

Download         Length: 294 bp

>AT156786 NZ_CP069071:c697420-697184 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References