Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1214763..1215351 Replicon chromosome
Accession NZ_CP053396
Organism Helicobacter pylori strain HPY

Toxin (Protein)


Gene name TfiT Uniprot ID A0A6M5U7W9
Locus tag HK440_RS05700 Protein ID WP_001917619.1
Coordinates 1214763..1215044 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID A0A6M5U3S5
Locus tag HK440_RS05705 Protein ID WP_001917618.1
Coordinates 1215037..1215351 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK440_RS05665 1209974..1210237 + 264 WP_001917625.1 hypothetical protein -
HK440_RS05670 1210234..1210533 + 300 WP_000660136.1 hypothetical protein -
HK440_RS05675 1210533..1211474 + 942 WP_001917624.1 Flp pilus assembly complex ATPase component TadA -
HK440_RS05680 1211471..1211926 + 456 WP_001917623.1 hypothetical protein -
HK440_RS05685 1211923..1212213 + 291 WP_001917622.1 hypothetical protein -
HK440_RS05690 1212214..1212771 + 558 WP_001917621.1 hypothetical protein -
HK440_RS05695 1212772..1214499 + 1728 WP_001917620.1 type IV secretory system conjugative DNA transfer family protein -
HK440_RS05700 1214763..1215044 - 282 WP_001917619.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HK440_RS05705 1215037..1215351 - 315 WP_001917618.1 hypothetical protein Antitoxin
HK440_RS05710 1215635..1217548 + 1914 WP_171407247.1 relaxase/mobilization nuclease domain-containing protein -
HK440_RS05715 1217573..1218757 - 1185 WP_001917617.1 hypothetical protein -
HK440_RS05720 1218789..1219073 - 285 WP_000394639.1 hypothetical protein -
HK440_RS05725 1219155..1219811 - 657 WP_001917616.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10877.77 Da        Isoelectric Point: 9.5726

>T156756 WP_001917619.1 NZ_CP053396:c1215044-1214763 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEVKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T156756 NZ_CP069070:2443696-2444040 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12168.59 Da        Isoelectric Point: 4.9439

>AT156756 WP_001917618.1 NZ_CP053396:c1215351-1215037 [Helicobacter pylori]
MSDIITDYSQYSEKQLHNFLNAIEKQWLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT156756 NZ_CP069070:2443454-2443702 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M5U7W9

Antitoxin

Source ID Structure
AlphaFold DB A0A6M5U3S5

References