156754

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1214373..1214961 Replicon chromosome
Accession NZ_CP053392
Organism Helicobacter pylori strain HP9192

Toxin (Protein)


Gene name TfiT Uniprot ID A0A6M5U7W9
Locus tag HK442_RS05690 Protein ID WP_001917619.1
Coordinates 1214373..1214654 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID A0A6M5U3S5
Locus tag HK442_RS05695 Protein ID WP_001917618.1
Coordinates 1214647..1214961 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HK442_RS05655 1209584..1209847 + 264 WP_001917625.1 hypothetical protein -
HK442_RS05660 1209844..1210143 + 300 WP_000660136.1 hypothetical protein -
HK442_RS05665 1210143..1211084 + 942 WP_001917624.1 Flp pilus assembly complex ATPase component TadA -
HK442_RS05670 1211081..1211536 + 456 WP_001917623.1 hypothetical protein -
HK442_RS05675 1211533..1211823 + 291 WP_001917622.1 hypothetical protein -
HK442_RS05680 1211824..1212381 + 558 WP_001917621.1 hypothetical protein -
HK442_RS05685 1212382..1214109 + 1728 WP_001917620.1 type IV secretory system conjugative DNA transfer family protein -
HK442_RS05690 1214373..1214654 - 282 WP_001917619.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HK442_RS05695 1214647..1214961 - 315 WP_001917618.1 hypothetical protein Antitoxin
HK442_RS05700 1215245..1217158 + 1914 WP_171407247.1 relaxase/mobilization nuclease domain-containing protein -
HK442_RS05705 1217183..1218367 - 1185 WP_001917617.1 hypothetical protein -
HK442_RS05710 1218399..1218683 - 285 WP_000394639.1 hypothetical protein -
HK442_RS05715 1218765..1219421 - 657 WP_001917616.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10877.77 Da        Isoelectric Point: 9.5726

>T156754 WP_001917619.1 NZ_CP053392:c1214654-1214373 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEVKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T156754 NZ_CP069070:c2352291-2351881 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12168.59 Da        Isoelectric Point: 4.9439

>AT156754 WP_001917618.1 NZ_CP053392:c1214961-1214647 [Helicobacter pylori]
MSDIITDYSQYSEKQLHNFLNAIEKQWLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT156754 NZ_CP069070:c2352517-2352284 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M5U7W9

Antitoxin

Source ID Structure
AlphaFold DB A0A6M5U3S5

References