Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2412283..2412884 Replicon chromosome
Accession NZ_CP053382
Organism Halomonas sp. MCCC 1A13316

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HNO52_RS11190 Protein ID WP_197565401.1
Coordinates 2412594..2412884 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HNO52_RS11185 Protein ID WP_197565400.1
Coordinates 2412283..2412588 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HNO52_RS11165 2408559..2408879 + 321 WP_197565396.1 helix-turn-helix domain-containing protein -
HNO52_RS11170 2408920..2409930 + 1011 WP_197565397.1 hypothetical protein -
HNO52_RS11175 2410106..2411386 + 1281 WP_197565398.1 hemolysin family protein -
HNO52_RS11180 2411454..2412233 + 780 WP_197565399.1 3'(2'),5'-bisphosphate nucleotidase CysQ -
HNO52_RS11185 2412283..2412588 - 306 WP_197565400.1 HigA family addiction module antidote protein Antitoxin
HNO52_RS11190 2412594..2412884 - 291 WP_197565401.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HNO52_RS11195 2413119..2413643 + 525 WP_197565402.1 DUF1269 domain-containing protein -
HNO52_RS11200 2413836..2414048 + 213 WP_197565403.1 hypothetical protein -
HNO52_RS11205 2414045..2414275 + 231 WP_197565404.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
HNO52_RS11210 2414272..2414748 + 477 WP_197565405.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
HNO52_RS11215 2414806..2415600 - 795 WP_197565406.1 glycosyl transferase -
HNO52_RS11220 2415826..2417172 + 1347 WP_197565407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - fcl / gmd 2369787..2617550 247763


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11410.73 Da        Isoelectric Point: 5.6004

>T156739 WP_197565401.1 NZ_CP053382:c2412884-2412594 [Halomonas sp. MCCC 1A13316]
MINNFRDAWLEDFFVDGRDHREIPSTIESALTRKLDIIEAAADESDLRVPPGNRFEHLQGRLEGKCSIRVYKQYRLIFEW
DGERAHNVYLDSHTYR

Download         Length: 291 bp

>T156739 NZ_CP069070:c1232362-1232051 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACACCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11691.72 Da        Isoelectric Point: 9.9766

>AT156739 WP_197565400.1 NZ_CP053382:c2412588-2412283 [Halomonas sp. MCCC 1A13316]
MFKINRKPTTVGEMLTHEFLEPFRLSQTKLAEKMGVSPRLVNELCRNKRAVTVDTALMLARVFGNSPPFWLNLQQKADLW
EALHDVKRLERIEKAQPLECA

Download         Length: 306 bp

>AT156739 NZ_CP069070:c1232682-1232362 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References