Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3293256..3293916 Replicon chromosome
Accession NZ_CP053378
Organism Serratia marcescens strain FY

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HMJ22_RS15545 Protein ID WP_171454389.1
Coordinates 3293563..3293916 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HMJ22_RS15540 Protein ID WP_171454388.1
Coordinates 3293256..3293558 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMJ22_RS15520 3288859..3289773 - 915 WP_171454386.1 branched-chain amino acid ABC transporter permease LivH -
HMJ22_RS15525 3289898..3291016 - 1119 WP_015378469.1 branched-chain amino acid ABC transporter substrate-binding protein -
HMJ22_RS15535 3291622..3292830 - 1209 WP_171454387.1 DUF4432 family protein -
HMJ22_RS15540 3293256..3293558 - 303 WP_171454388.1 XRE family transcriptional regulator Antitoxin
HMJ22_RS15545 3293563..3293916 - 354 WP_171454389.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HMJ22_RS15550 3294354..3295649 + 1296 WP_171454390.1 tricarballylate/proton symporter TcuC -
HMJ22_RS15555 3295676..3296482 + 807 WP_033632598.1 substrate-binding domain-containing protein -
HMJ22_RS15560 3296457..3297356 - 900 WP_171454391.1 LysR family transcriptional regulator -
HMJ22_RS15565 3297460..3297825 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13611.58 Da        Isoelectric Point: 9.0493

>T156733 WP_171454389.1 NZ_CP053378:c3293916-3293563 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRSCVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRVGM
VLCAGNKAGDEKRFYDRMLQIADREFTNWLNTLKEKE

Download         Length: 354 bp

>T156733 NZ_CP069070:c758020-757712 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11128.94 Da        Isoelectric Point: 5.1891

>AT156733 WP_171454388.1 NZ_CP053378:c3293558-3293256 [Serratia marcescens]
MGRTLEQLIADEKPEVVAEAQAMATDIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT156733 NZ_CP069070:c758252-758007 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References